Motif ID: Lhx4
Z-value: 0.789
Transcription factors associated with Lhx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Lhx4 | ENSMUSG00000026468.8 | Lhx4 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 83 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.2 | 3.5 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.9 | 2.7 | GO:0030210 | heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
| 0.2 | 2.4 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 2.4 | GO:0030901 | midbrain development(GO:0030901) |
| 0.4 | 2.2 | GO:0001661 | conditioned taste aversion(GO:0001661) amygdala development(GO:0021764) |
| 0.3 | 2.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 2.2 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
| 0.5 | 2.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.2 | 2.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 1.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.5 | 1.6 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 0.2 | 1.5 | GO:0061551 | trigeminal ganglion development(GO:0061551) |
| 0.2 | 1.5 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.3 | 1.4 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.2 | 1.4 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 1.4 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.3 | 1.3 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 0.3 | 1.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 1.2 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 36 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 2.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.7 | 2.2 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.0 | 2.0 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 1.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 1.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 1.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 1.0 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 0.9 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.7 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.7 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.2 | 0.5 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.0 | 0.5 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 0.5 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.5 | GO:0010369 | chromocenter(GO:0010369) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 60 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.9 | 3.5 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 2.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 2.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 2.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.7 | 2.2 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.3 | 2.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.3 | 2.2 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.0 | 2.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 2.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 2.0 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.8 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.1 | 1.7 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.3 | 1.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 1.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.5 | 1.4 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 1.4 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 1.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 1.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in C2:CP category:
Showing 1 to 18 of 18 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.6 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.3 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.2 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.1 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.0 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.7 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.7 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.6 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.5 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.4 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 24 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 2.4 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.1 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 1.1 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.0 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.7 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 0.6 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.6 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 0.6 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.4 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.4 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.4 | REACTOME_ARMS_MEDIATED_ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 0.4 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
