Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.507

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.306.1e-02Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.143.9e-01Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.066.9e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_13398688 3.032 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr18_+_57468478 2.795 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr14_+_80000292 2.573 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr7_+_66365905 2.242 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr7_-_46667375 2.240 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr11_-_87359011 2.033 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr1_-_158356258 1.903 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr7_-_45103747 1.879 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chrX_-_143933089 1.803 ENSMUST00000087313.3
 Dcx
doublecortin
chr16_+_11406618 1.744 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr8_-_67910911 1.702 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr2_-_160619971 1.669 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr13_+_67833235 1.599 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chr2_+_3770673 1.512 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr8_+_34054622 1.428 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr13_+_77135513 1.417 ENSMUST00000168779.1
 2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr13_-_105271039 1.373 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr4_+_102589687 1.275 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr3_+_121953213 1.186 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr1_+_58210397 1.164 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.0 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 2.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 2.7 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 2.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 2.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 2.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.4 GO:0042428 serotonin metabolic process(GO:0042428)
0.4 1.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 1.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 1.1 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.1 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.3 1.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 1.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 1.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.0 GO:0030901 midbrain development(GO:0030901)
0.2 0.9 GO:0051684 maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0042581 specific granule(GO:0042581)
0.0 1.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.2 0.7 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 0.5 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0038191 neuropilin binding(GO:0038191)
0.9 2.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 2.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 1.9 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 1.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.3 1.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 1.0 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 1.0 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 0.8 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0030331 estrogen receptor binding(GO:0030331)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.2 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 3.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 2.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 2.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.0 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 0.8 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.7 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.1 0.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds