Motif ID: Lhx8

Z-value: 0.655


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.333.7e-02Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_23415400 2.516 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr13_-_66851513 2.450 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr7_+_91090697 2.438 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 2.393 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr2_+_65620829 2.374 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr3_-_73056943 2.364 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr2_-_52558539 2.336 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr1_+_72284367 1.909 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr13_-_66852017 1.764 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr15_+_21111452 1.745 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_66227573 1.687 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr5_+_137553517 1.669 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr1_+_6487231 1.637 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr8_+_34054622 1.608 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr2_-_114013619 1.431 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr13_-_62466709 1.404 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chrX_+_101640056 1.404 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr6_-_136173492 1.351 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr12_+_38783455 1.271 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr17_-_90088343 1.221 ENSMUST00000173917.1
 Nrxn1
neurexin I

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 2.3 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.6 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.5 1.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 1.4 GO:0007601 visual perception(GO:0007601)
0.3 1.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.3 0.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 0.8 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.8 GO:0042588 zymogen granule(GO:0042588)
0.1 1.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 1.4 GO:0005922 connexon complex(GO:0005922)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0034657 GID complex(GO:0034657)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 2.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 1.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 0.9 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.0 0.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK