Motif ID: Maf_Nrl

Z-value: 0.616

Transcription factors associated with Maf_Nrl:

Gene SymbolEntrez IDGene Name
Maf ENSMUSG00000055435.6 Maf
Nrl ENSMUSG00000040632.9 Nrl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafmm10_v2_chr8_-_115707778_115707794-0.408.7e-03Click!


Activity profile for motif Maf_Nrl.

activity profile for motif Maf_Nrl


Sorted Z-values histogram for motif Maf_Nrl

Sorted Z-values for motif Maf_Nrl



Network of associatons between targets according to the STRING database.



First level regulatory network of Maf_Nrl

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 4.037 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_+_90203980 3.910 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr7_-_75308373 2.338 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr14_-_49525840 2.280 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4


chr15_-_93519499 2.115 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr11_-_77725281 2.090 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr7_+_121707189 1.742 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr15_-_67113909 1.724 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_-_118373347 1.661 ENSMUST00000039160.2
 Gpr176
G protein-coupled receptor 176
chr2_-_156887172 1.485 ENSMUST00000109561.3
 Sla2
Src-like-adaptor 2
chr3_-_79145875 1.430 ENSMUST00000118340.1
 Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_-_156887056 1.426 ENSMUST00000029164.2
 Sla2
Src-like-adaptor 2
chr15_+_89453913 1.346 ENSMUST00000023291.5
 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr11_+_76202007 1.302 ENSMUST00000094014.3
 Fam57a
family with sequence similarity 57, member A
chr16_+_78930940 1.255 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr11_+_76202084 1.222 ENSMUST00000169560.1
 Fam57a
family with sequence similarity 57, member A
chr2_-_151632471 1.193 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr11_-_79059872 1.092 ENSMUST00000141409.1
 Ksr1
kinase suppressor of ras 1
chr12_-_111672290 1.040 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr6_-_138422898 1.011 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.8 GO:0015671 oxygen transport(GO:0015671)
0.1 4.1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 2.9 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.2 2.3 GO:0060539 diaphragm development(GO:0060539)
0.7 2.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.3 2.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 1.8 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.0 1.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.3 1.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.5 1.4 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 1.3 GO:0046958 nonassociative learning(GO:0046958)
0.1 1.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 1.2 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.2 1.1 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 1.1 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.3 1.0 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.2 1.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.0 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 1.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.3 0.9 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.8 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.3 GO:0005770 late endosome(GO:0005770)
0.0 4.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0071565 nBAF complex(GO:0071565)
0.1 0.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.8 GO:0045202 synapse(GO:0045202)
0.2 0.7 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.2 0.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.7 GO:0044305 calyx of Held(GO:0044305)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0005771 multivesicular body(GO:0005771)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.6 GO:0097542 ciliary tip(GO:0097542)
0.0 0.6 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.3 3.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.1 3.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.8 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.4 1.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.3 1.0 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.0 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 1.0 GO:0015197 peptide transporter activity(GO:0015197)
0.1 1.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 2.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_ATM_PATHWAY ATM pathway
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.4 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.2 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 0.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors