Motif ID: Mafb

Z-value: 0.664


Transcription factors associated with Mafb:

Gene SymbolEntrez IDGene Name
Mafb ENSMUSG00000074622.3 Mafb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafbmm10_v2_chr2_-_160367057_1603670730.704.6e-07Click!


Activity profile for motif Mafb.

activity profile for motif Mafb


Sorted Z-values histogram for motif Mafb

Sorted Z-values for motif Mafb



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_120202104 3.694 ENSMUST00000033198.5
 Crym
crystallin, mu
chr18_+_65873478 2.613 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr14_+_80000292 2.034 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr11_+_75531690 2.018 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr11_-_116307168 2.015 ENSMUST00000124281.1
 Exoc7
exocyst complex component 7
chr7_+_130936172 1.939 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr19_+_26753588 1.932 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_-_5510467 1.872 ENSMUST00000070172.4
 Snx32
sorting nexin 32
chr17_-_6477102 1.845 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_6270475 1.809 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr17_+_3532554 1.787 ENSMUST00000168560.1
 Cldn20
claudin 20
chr4_-_136886187 1.771 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr2_+_170731807 1.765 ENSMUST00000029075.4
 Dok5
docking protein 5
chr9_-_18473559 1.724 ENSMUST00000034647.4
 Zfp558
zinc finger protein 558
chr7_-_141010759 1.641 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr10_-_42276688 1.636 ENSMUST00000175881.1
ENSMUST00000056974.3
 Foxo3

forkhead box O3

chr10_+_40349265 1.588 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr3_+_94398517 1.539 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr2_-_31116289 1.528 ENSMUST00000149196.1
 Fnbp1
formin binding protein 1
chr7_+_4137032 1.509 ENSMUST00000128756.1
ENSMUST00000132086.1
ENSMUST00000037472.6
ENSMUST00000117274.1
ENSMUST00000121270.1
 Leng8




leukocyte receptor cluster (LRC) member 8





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 3.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 2.8 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.9 2.6 GO:0061744 motor behavior(GO:0061744) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.4 2.1 GO:0051012 microtubule sliding(GO:0051012)
0.2 2.0 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0 2.0 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.3 1.9 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 1.8 GO:0009405 pathogenesis(GO:0009405)
0.1 1.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 1.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.7 GO:0015807 L-amino acid transport(GO:0015807)
0.0 1.7 GO:0007605 sensory perception of sound(GO:0007605)
0.1 1.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 1.6 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 1.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.6 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.5 1.5 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.4 1.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0042581 specific granule(GO:0042581)
0.1 2.0 GO:0000145 exocyst(GO:0000145)
0.1 1.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.8 GO:0071564 npBAF complex(GO:0071564)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 1.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.5 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.3 GO:0031941 filamentous actin(GO:0031941)
0.1 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.2 GO:0005771 multivesicular body(GO:0005771)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.3 1.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.9 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 3.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 2.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 2.3 GO:0015643 toxic substance binding(GO:0015643)
0.4 2.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 1.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.4 1.3 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.3 1.3 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.3 1.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 1.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 2.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 2.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 2.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 1.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.5 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type