Motif ID: Max_Mycn

Z-value: 3.397

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maxmm10_v2_chr12_-_76962178_76962248-0.462.4e-03Click!
Mycnmm10_v2_chr12_-_12940600_129406160.287.1e-02Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_135251209 31.839 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr5_+_140607334 28.595 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_137796350 26.016 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr7_+_144896523 24.996 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr4_-_143299498 24.839 ENSMUST00000030317.7
 Pdpn
podoplanin
chr4_-_143299463 22.825 ENSMUST00000119654.1
 Pdpn
podoplanin
chr12_+_117843873 21.003 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr11_-_89302545 20.739 ENSMUST00000061728.3
 Nog
noggin
chr8_+_27260327 18.951 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr14_-_79301623 18.465 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr8_-_46294592 18.264 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr10_-_30842765 18.165 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr10_+_127063599 17.910 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr11_-_94601862 17.891 ENSMUST00000103164.3
 Acsf2
acyl-CoA synthetase family member 2
chr16_+_30065333 17.673 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr10_-_77113676 17.497 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr17_+_46496753 16.748 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr5_+_114130386 16.670 ENSMUST00000031587.6
 Ung
uracil DNA glycosylase
chr3_+_104638658 16.193 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr9_-_8004585 15.927 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 643 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 51.0 GO:0006414 translational elongation(GO:0006414)
9.5 47.7 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
11.4 45.7 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
6.5 38.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
3.8 34.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
3.0 33.1 GO:0006228 UTP biosynthetic process(GO:0006228)
8.1 32.5 GO:0010288 response to lead ion(GO:0010288)
10.6 31.8 GO:1990523 bone regeneration(GO:1990523)
1.0 31.1 GO:0046677 response to antibiotic(GO:0046677)
7.7 30.8 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
5.7 28.6 GO:0007386 compartment pattern specification(GO:0007386)
0.9 27.8 GO:0048255 mRNA stabilization(GO:0048255)
4.8 24.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
6.0 23.9 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
2.0 23.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.7 23.3 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
1.8 22.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 22.1 GO:0016925 protein sumoylation(GO:0016925)
1.4 21.5 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
5.2 20.7 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 267 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 144.4 GO:0005576 extracellular region(GO:0005576)
0.1 142.1 GO:0005739 mitochondrion(GO:0005739)
0.2 79.5 GO:0005925 focal adhesion(GO:0005925)
0.7 57.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 55.4 GO:0005759 mitochondrial matrix(GO:0005759)
1.0 55.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
4.8 43.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.8 42.6 GO:0000791 euchromatin(GO:0000791)
0.3 42.6 GO:0001650 fibrillar center(GO:0001650)
3.8 41.3 GO:0005642 annulate lamellae(GO:0005642)
1.9 39.0 GO:0031527 filopodium membrane(GO:0031527)
0.8 36.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
5.9 35.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 34.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
8.1 32.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.8 30.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
2.1 29.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 23.9 GO:0016363 nuclear matrix(GO:0016363)
0.5 23.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 22.0 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 415 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 85.5 GO:0003735 structural constituent of ribosome(GO:0003735)
3.4 82.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 56.2 GO:0003723 RNA binding(GO:0003723)
1.1 53.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
4.3 47.6 GO:0015250 water channel activity(GO:0015250)
0.8 37.9 GO:0016831 carboxy-lyase activity(GO:0016831)
1.9 33.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.5 33.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.8 33.0 GO:0045182 translation regulator activity(GO:0045182)
0.8 32.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 31.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
10.3 30.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
7.5 30.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.6 29.7 GO:0051920 peroxiredoxin activity(GO:0051920)
0.4 27.1 GO:0019955 cytokine binding(GO:0019955)
2.1 24.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
3.9 23.6 GO:0043426 MRF binding(GO:0043426)
7.8 23.5 GO:0035939 microsatellite binding(GO:0035939)
5.7 22.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.8 22.8 GO:0008432 JUN kinase binding(GO:0008432)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 186.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 62.3 PID_INSULIN_PATHWAY Insulin Pathway
3.9 54.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.2 36.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.9 31.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 31.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 30.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.5 26.5 PID_BMP_PATHWAY BMP receptor signaling
0.9 25.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.6 25.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 21.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.7 21.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.3 20.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 19.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.6 16.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.6 12.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.3 12.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 12.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 12.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 12.1 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 73.6 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.5 69.4 REACTOME_G1_PHASE Genes involved in G1 Phase
1.2 60.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.6 53.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 50.1 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
2.1 45.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
3.1 42.9 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.5 39.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
1.9 39.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 38.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.5 34.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 33.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.9 31.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
1.7 28.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
1.0 27.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.5 26.0 REACTOME_TRANSLATION Genes involved in Translation
1.6 25.6 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.9 25.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.5 24.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.5 22.9 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle