Motif ID: Maz_Zfp281

Z-value: 1.711

Transcription factors associated with Maz_Zfp281:

Gene SymbolEntrez IDGene Name
Maz ENSMUSG00000030678.6 Maz
Zfp281 ENSMUSG00000041483.8 Zfp281

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mazmm10_v2_chr7_-_127026479_1270264960.729.8e-08Click!
Zfp281mm10_v2_chr1_+_136624901_1366249490.048.0e-01Click!


Activity profile for motif Maz_Zfp281.

activity profile for motif Maz_Zfp281


Sorted Z-values histogram for motif Maz_Zfp281

Sorted Z-values for motif Maz_Zfp281



Network of associatons between targets according to the STRING database.



First level regulatory network of Maz_Zfp281

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 13.625 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_+_19094594 11.846 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr2_+_71529085 11.785 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr17_+_85620816 11.475 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr10_-_120476469 10.924 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr10_+_108332173 10.763 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr8_+_12395287 10.550 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr6_+_108660616 10.246 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr17_+_85613432 9.966 ENSMUST00000176081.1
 Six3
sine oculis-related homeobox 3
chr12_-_80112998 9.919 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr16_+_84774123 9.427 ENSMUST00000114195.1
 Jam2
junction adhesion molecule 2
chr7_-_144939823 8.904 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_89302545 8.629 ENSMUST00000061728.3
 Nog
noggin
chr7_-_116308241 8.582 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr11_+_78322965 8.556 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr14_-_118052235 8.541 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr6_-_72788952 8.347 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr11_-_102579461 8.116 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr14_-_98169542 8.009 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr19_-_59170978 7.908 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,062 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.0 27.0 GO:0097402 neuroblast migration(GO:0097402)
8.0 24.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.6 22.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.9 18.5 GO:0038092 nodal signaling pathway(GO:0038092)
1.8 18.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.6 16.5 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.7 16.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
2.7 16.4 GO:0030916 otic vesicle formation(GO:0030916)
2.3 16.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
4.0 15.9 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
3.0 14.9 GO:0048382 mesendoderm development(GO:0048382)
0.7 14.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.4 13.9 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
4.6 13.8 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.2 13.6 GO:0006105 succinate metabolic process(GO:0006105)
1.0 13.4 GO:0014856 skeletal muscle cell proliferation(GO:0014856)
0.6 13.1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.3 12.7 GO:0051310 metaphase plate congression(GO:0051310)
0.6 12.5 GO:0042474 middle ear morphogenesis(GO:0042474)
1.4 12.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 354 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 174.0 GO:0005634 nucleus(GO:0005634)
0.2 88.0 GO:0005667 transcription factor complex(GO:0005667)
0.4 32.1 GO:0005844 polysome(GO:0005844)
0.3 26.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 25.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 20.6 GO:0031012 extracellular matrix(GO:0031012)
0.6 15.5 GO:0001741 XY body(GO:0001741)
1.1 11.9 GO:0005915 zonula adherens(GO:0005915)
1.6 11.5 GO:0042627 chylomicron(GO:0042627)
0.3 11.3 GO:0000791 euchromatin(GO:0000791)
0.1 10.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 10.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.9 10.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.8 10.0 GO:0046930 pore complex(GO:0046930)
0.2 9.9 GO:0032420 stereocilium(GO:0032420)
0.1 9.8 GO:0005681 spliceosomal complex(GO:0005681)
0.5 9.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
3.1 9.2 GO:0005577 fibrinogen complex(GO:0005577)
1.3 9.2 GO:0001740 Barr body(GO:0001740)
0.7 9.1 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 560 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 54.9 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.1 37.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 36.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 24.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 22.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.4 21.8 GO:0003680 AT DNA binding(GO:0003680)
0.9 21.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
3.3 19.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.8 18.8 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.7 18.8 GO:0071837 HMG box domain binding(GO:0071837)
2.7 18.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 17.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 16.2 GO:0008432 JUN kinase binding(GO:0008432)
0.3 15.8 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.7 15.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 15.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.4 14.4 GO:0043426 MRF binding(GO:0043426)
2.1 14.4 GO:0034056 estrogen response element binding(GO:0034056)
0.3 14.0 GO:0003727 single-stranded RNA binding(GO:0003727)
1.1 13.7 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 44.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 40.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.6 32.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.6 32.1 PID_BMP_PATHWAY BMP receptor signaling
0.7 31.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 31.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 30.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 26.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
1.7 24.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 23.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 21.1 PID_CDC42_PATHWAY CDC42 signaling events
0.4 20.5 PID_PLK1_PATHWAY PLK1 signaling events
1.0 19.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.4 18.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 17.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.6 15.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 14.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.3 13.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.3 12.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.4 12.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 33.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 30.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 29.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 28.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.9 26.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.9 26.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 26.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 22.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.8 21.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 19.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 18.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 15.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 14.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.7 13.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.6 13.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 13.3 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.6 13.1 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.5 12.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.6 12.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3 11.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription