Motif ID: Mbd2

Z-value: 1.039


Transcription factors associated with Mbd2:

Gene SymbolEntrez IDGene Name
Mbd2 ENSMUSG00000024513.10 Mbd2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mbd2mm10_v2_chr18_+_70568189_705683980.029.0e-01Click!


Activity profile for motif Mbd2.

activity profile for motif Mbd2


Sorted Z-values histogram for motif Mbd2

Sorted Z-values for motif Mbd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mbd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_108003414 8.410 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr5_-_115194283 3.014 ENSMUST00000112113.1
 Cabp1
calcium binding protein 1
chr11_-_75796048 2.994 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr12_-_108003594 2.982 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr5_+_30588078 2.889 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr4_-_120747248 2.698 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr7_-_126082406 2.693 ENSMUST00000073935.5
 Gsg1l
GSG1-like
chr5_+_37028329 2.553 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr5_+_36868467 2.497 ENSMUST00000031003.7
 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr6_-_126740151 2.421 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chrX_+_152144240 2.311 ENSMUST00000168786.1
ENSMUST00000112605.1
ENSMUST00000112604.1
 Iqsec2


IQ motif and Sec7 domain 2


chr14_-_39472825 2.239 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr1_+_75375271 2.207 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr2_+_35622160 2.029 ENSMUST00000112992.2
 Dab2ip
disabled 2 interacting protein
chr11_+_57645417 2.026 ENSMUST00000066987.7
ENSMUST00000108846.1
 Galnt10

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10

chr15_-_28025834 2.018 ENSMUST00000090247.5
 Trio
triple functional domain (PTPRF interacting)
chr19_+_56722372 1.978 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr2_+_35622010 1.882 ENSMUST00000091010.5
 Dab2ip
disabled 2 interacting protein
chr11_+_7063423 1.863 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr17_-_47924460 1.853 ENSMUST00000113262.1
 Foxp4
forkhead box P4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 4.7 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.5 4.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.4 4.3 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
0.8 3.9 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.6 3.8 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
0.1 3.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 3.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 2.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.7 2.7 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 2.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 2.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 2.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.5 2.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 2.0 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.3 2.0 GO:0016266 O-glycan processing(GO:0016266)
0.3 1.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 1.9 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.6 1.8 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.6 1.8 GO:0035574 histone H4-K20 demethylation(GO:0035574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 5.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.5 4.5 GO:0045298 tubulin complex(GO:0045298)
1.0 3.9 GO:1990032 parallel fiber(GO:1990032)
0.3 3.7 GO:1990909 Wnt signalosome(GO:1990909)
0.1 3.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.0 GO:0031201 SNARE complex(GO:0031201)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.8 GO:0071565 nBAF complex(GO:0071565)
0.1 2.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 2.1 GO:0005776 autophagosome(GO:0005776)
0.1 1.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 1.8 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.2 1.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 4.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 4.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.6 4.5 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 3.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 3.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 2.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 2.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.3 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.2 GO:0045499 chemorepellent activity(GO:0045499)
0.4 2.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.7 2.0 GO:0051379 epinephrine binding(GO:0051379)
0.1 2.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 3.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.6 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID_P53_REGULATION_PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 2.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 2.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.0 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 1.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.9 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.9 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 0.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.7 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation