Motif ID: Mecp2

Z-value: 1.934


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_74085652-0.124.7e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_25250720 13.896 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr11_-_89302545 12.799 ENSMUST00000061728.3
 Nog
noggin
chr6_-_72788952 12.485 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr11_+_98412461 11.283 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr11_+_112782182 10.275 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr6_-_72789240 9.640 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr10_-_42583628 9.004 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr5_+_127241807 8.741 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr11_-_68386821 8.613 ENSMUST00000021284.3
 Ntn1
netrin 1
chr3_-_101110278 8.576 ENSMUST00000102694.3
 Ptgfrn
prostaglandin F2 receptor negative regulator
chr2_+_27886416 8.032 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr2_+_91457501 8.023 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr2_+_59612034 7.962 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr15_-_103366763 7.475 ENSMUST00000023128.6
 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr8_-_87959560 7.339 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr17_-_32166879 7.195 ENSMUST00000087723.3
 Notch3
notch 3
chr4_+_154960915 6.813 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_-_118237016 6.802 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr8_-_90348343 6.734 ENSMUST00000109621.3
 Tox3
TOX high mobility group box family member 3
chr17_+_83215271 6.626 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,075 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 21.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.3 16.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
2.0 15.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.9 14.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
3.4 13.7 GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393)
3.2 12.6 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
4.1 12.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.3 12.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 12.2 GO:0051028 mRNA transport(GO:0051028)
3.0 12.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
2.4 12.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
3.8 11.5 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
5.6 11.3 GO:0072197 ureter morphogenesis(GO:0072197)
3.8 11.3 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
1.9 11.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.5 10.7 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838)
0.4 10.7 GO:0006270 DNA replication initiation(GO:0006270)
1.0 10.5 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
2.0 9.9 GO:0048382 mesendoderm development(GO:0048382)
0.9 9.8 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 376 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.3 GO:0070062 extracellular exosome(GO:0070062)
0.2 47.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 42.1 GO:0005634 nucleus(GO:0005634)
0.2 37.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.3 33.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 21.7 GO:0001741 XY body(GO:0001741)
0.1 21.4 GO:0005925 focal adhesion(GO:0005925)
1.6 20.8 GO:0043219 lateral loop(GO:0043219)
0.1 19.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 18.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 17.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 14.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 14.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 13.9 GO:0005844 polysome(GO:0005844)
1.3 13.8 GO:0016600 flotillin complex(GO:0016600)
2.1 12.6 GO:0061689 tricellular tight junction(GO:0061689)
0.1 12.3 GO:0016607 nuclear speck(GO:0016607)
3.5 10.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 10.6 GO:0005581 collagen trimer(GO:0005581)
0.4 9.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 601 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 40.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.2 35.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3 29.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 19.2 GO:0003735 structural constituent of ribosome(GO:0003735)
2.3 18.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 17.9 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.2 17.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.8 14.4 GO:0017166 vinculin binding(GO:0017166)
0.8 13.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
1.7 12.0 GO:0034056 estrogen response element binding(GO:0034056)
0.1 12.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 11.8 GO:0008013 beta-catenin binding(GO:0008013)
0.3 11.7 GO:0019955 cytokine binding(GO:0019955)
0.1 11.6 GO:0042393 histone binding(GO:0042393)
3.8 11.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
1.3 11.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 11.1 GO:0042056 chemoattractant activity(GO:0042056)
0.6 11.0 GO:0008483 transaminase activity(GO:0008483)
0.9 10.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.8 10.2 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 40.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 39.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
1.0 29.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.6 28.7 PID_BMP_PATHWAY BMP receptor signaling
0.5 26.9 PID_PLK1_PATHWAY PLK1 signaling events
0.4 24.3 PID_E2F_PATHWAY E2F transcription factor network
0.4 24.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 20.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 20.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.6 18.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 18.6 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.5 16.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 13.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 12.6 PID_FGF_PATHWAY FGF signaling pathway
0.9 12.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 11.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 11.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 10.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 10.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 9.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 27.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 26.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 20.0 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.8 19.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.6 18.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.6 17.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 16.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 16.5 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.9 13.7 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
1.2 13.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 13.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.8 12.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.7 11.9 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 10.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.4 9.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 9.4 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.6 9.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 8.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 8.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 8.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway