Motif ID: Mef2b

Z-value: 0.711


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.381.3e-02Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.677 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_142899985 5.349 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr7_-_103843154 3.850 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chrY_-_1286563 3.839 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_172043466 3.729 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 3.180 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr1_+_187609028 3.014 ENSMUST00000110939.1
 Esrrg
estrogen-related receptor gamma
chr12_-_111672290 2.905 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr7_-_144738478 2.645 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr18_+_50030977 2.420 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr2_-_94264713 2.171 ENSMUST00000129661.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr3_+_40800013 2.111 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chrX_+_10717390 2.049 ENSMUST00000115524.1
ENSMUST00000008179.6
 Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr8_+_31089471 1.970 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr5_+_24985840 1.965 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr9_-_110742577 1.947 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chrX_+_10717451 1.923 ENSMUST00000156321.1
 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr2_-_94264745 1.862 ENSMUST00000134563.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr2_-_57124003 1.848 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr7_-_144738520 1.744 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 5.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.9 4.4 GO:0015705 iodide transport(GO:0015705)
0.2 4.0 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.8 3.9 GO:0015671 oxygen transport(GO:0015671)
0.1 3.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.6 3.2 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.2 3.2 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 3.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.5 2.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.5 2.6 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.0 2.6 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 2.5 GO:0060271 cilium morphogenesis(GO:0060271)
0.3 2.1 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.7 2.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 1.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.5 1.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.5 1.8 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 4.8 GO:0034707 chloride channel complex(GO:0034707)
0.5 3.9 GO:0005833 hemoglobin complex(GO:0005833)
0.0 3.8 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
1.1 3.2 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 3.2 GO:0035976 AP1 complex(GO:0035976)
0.0 2.8 GO:0043209 myelin sheath(GO:0043209)
0.6 2.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.4 2.1 GO:0098536 deuterosome(GO:0098536)
0.1 2.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 1.6 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 1.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0030118 clathrin coat(GO:0030118)
0.0 1.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.3 GO:0035240 dopamine binding(GO:0035240)
1.1 4.4 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.0 3.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 3.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 3.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 3.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.7 2.9 GO:0004111 creatine kinase activity(GO:0004111)
0.4 2.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.7 2.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 1.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.9 GO:0017046 peptide hormone binding(GO:0017046)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.4 1.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 1.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 3.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.2 3.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits