Motif ID: Meis1

Z-value: 0.895


Transcription factors associated with Meis1:

Gene SymbolEntrez IDGene Name
Meis1 ENSMUSG00000020160.12 Meis1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis1mm10_v2_chr11_-_19018714_190188280.417.4e-03Click!


Activity profile for motif Meis1.

activity profile for motif Meis1


Sorted Z-values histogram for motif Meis1

Sorted Z-values for motif Meis1



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 9.146 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr1_-_138842429 3.244 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr11_-_64436653 3.102 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr3_+_125404292 2.570 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr9_+_87022014 2.393 ENSMUST00000168529.2
ENSMUST00000174724.1
ENSMUST00000173126.1
 Cyb5r4


cytochrome b5 reductase 4


chr17_-_45659312 2.338 ENSMUST00000120717.1
 Capn11
calpain 11
chr11_+_44617310 2.231 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr14_-_98169542 2.122 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr16_-_50732707 1.969 ENSMUST00000169791.2
 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr8_+_127064107 1.925 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr7_+_51621830 1.851 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr8_+_127064022 1.830 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr6_+_4747306 1.724 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr14_+_13284774 1.700 ENSMUST00000070323.5
 Synpr
synaptoporin
chr3_+_109123104 1.675 ENSMUST00000029477.6
 Slc25a24
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr15_+_23036449 1.593 ENSMUST00000164787.1
 Cdh18
cadherin 18
chr2_-_180776900 1.488 ENSMUST00000108878.1
 Bhlhe23
basic helix-loop-helix family, member e23
chr6_-_136941494 1.458 ENSMUST00000111892.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_+_70388305 1.426 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr3_+_134828993 1.404 ENSMUST00000029822.4
 Tacr3
tachykinin receptor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.6 3.8 GO:0003383 apical constriction(GO:0003383)
0.6 3.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 2.4 GO:0006739 NADP metabolic process(GO:0006739)
0.7 2.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 1.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.3 1.7 GO:0015867 ATP transport(GO:0015867)
0.2 1.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.6 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.5 1.5 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 1.5 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.2 1.4 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 1.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.4 1.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 1.3 GO:0060009 Sertoli cell development(GO:0060009)
0.2 1.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 1.2 GO:0007296 vitellogenesis(GO:0007296)
0.4 1.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.8 GO:0033269 internode region of axon(GO:0033269)
0.1 3.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 3.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.5 GO:0000792 heterochromatin(GO:0000792)
0.1 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.1 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.0 GO:0097546 ciliary base(GO:0097546)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.2 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.7 GO:0032156 septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 2.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 2.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 2.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 2.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 2.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.3 2.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 1.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.2 1.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.4 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.3 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.4 1.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 1.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 1.1 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0 1.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 0.9 GO:0004348 glucosylceramidase activity(GO:0004348)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.0 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.2 PID_TRAIL_PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.9 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins