Motif ID: Mga

Z-value: 0.609


Transcription factors associated with Mga:

Gene SymbolEntrez IDGene Name
Mga ENSMUSG00000033943.9 Mga

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mgamm10_v2_chr2_+_119897212_1198973050.381.5e-02Click!


Activity profile for motif Mga.

activity profile for motif Mga


Sorted Z-values histogram for motif Mga

Sorted Z-values for motif Mga



Network of associatons between targets according to the STRING database.



First level regulatory network of Mga

PNG image of the network

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Top targets:


Showing 1 to 20 of 80 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_43869993 2.545 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr6_-_41636389 2.066 ENSMUST00000031902.5
 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr5_-_138619702 1.885 ENSMUST00000063262.4
 Zfp68
zinc finger protein 68
chrX_+_35888808 1.783 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr8_+_12984246 1.673 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr4_+_95967322 1.625 ENSMUST00000107083.1
 Hook1
hook homolog 1 (Drosophila)
chr5_-_138619751 1.594 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68

chr14_+_64652524 1.422 ENSMUST00000100473.4
 Kif13b
kinesin family member 13B
chr13_+_29016267 1.403 ENSMUST00000140415.1
 A330102I10Rik
RIKEN cDNA A330102I10 gene
chr11_+_49203465 1.347 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
 Zfp62


zinc finger protein 62


chr5_-_138619653 1.269 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr9_+_57940104 1.156 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr14_-_52279238 1.118 ENSMUST00000167116.1
ENSMUST00000100631.4
 Rab2b

RAB2B, member RAS oncogene family

chr11_+_49203285 1.092 ENSMUST00000109198.1
ENSMUST00000137061.2
 Zfp62

zinc finger protein 62

chr6_-_149188648 1.057 ENSMUST00000095319.3
ENSMUST00000141346.1
ENSMUST00000111535.1
 Amn1


antagonist of mitotic exit network 1


chr14_-_18893623 0.994 ENSMUST00000177259.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr10_+_81575306 0.985 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr4_+_43381979 0.961 ENSMUST00000035645.5
ENSMUST00000144911.1
 Rusc2

RUN and SH3 domain containing 2

chr3_+_13946368 0.941 ENSMUST00000171075.1
ENSMUST00000108372.2
 Ralyl

RALY RNA binding protein-like

chr8_+_3393018 0.939 ENSMUST00000004684.6
ENSMUST00000145394.1
 Arhgef18

rho/rac guanine nucleotide exchange factor (GEF) 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0016236 macroautophagy(GO:0016236)
0.3 2.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 1.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 1.8 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 1.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.6 GO:0008333 endosome to lysosome transport(GO:0008333)
0.2 1.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 1.1 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.1 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.2 1.0 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.9 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.8 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.8 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 0.7 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.2 0.6 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.5 GO:0002946 tRNA C5-cytosine methylation(GO:0002946)
0.1 0.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 1.6 GO:0070695 FHF complex(GO:0070695)
0.1 1.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.0 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 1.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0005262 calcium channel activity(GO:0005262)
0.2 0.9 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.8 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.6 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.5 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.4 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.1 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)