Motif ID: Mnt

Z-value: 0.904


Transcription factors associated with Mnt:

Gene SymbolEntrez IDGene Name
Mnt ENSMUSG00000000282.6 Mnt

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mntmm10_v2_chr11_+_74830920_748310050.444.4e-03Click!


Activity profile for motif Mnt.

activity profile for motif Mnt


Sorted Z-values histogram for motif Mnt

Sorted Z-values for motif Mnt



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnt

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_4300462 5.667 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr15_+_81811414 5.373 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr11_+_69095217 5.230 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr8_-_29219338 4.980 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr17_-_66077022 4.660 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr9_-_121495678 4.574 ENSMUST00000035120.4
 Cck
cholecystokinin
chr17_-_56476462 4.548 ENSMUST00000067538.5
 Ptprs
protein tyrosine phosphatase, receptor type, S
chr4_-_53159885 4.503 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr3_-_89773221 3.956 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr11_+_3332426 3.936 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr12_+_70825492 3.888 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr14_-_78536762 3.874 ENSMUST00000123853.1
 Akap11
A kinase (PRKA) anchor protein 11
chr6_+_17463749 3.694 ENSMUST00000115443.1
 Met
met proto-oncogene
chr17_-_90455872 3.682 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr5_-_136170634 3.608 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr14_-_78536854 3.503 ENSMUST00000022593.5
 Akap11
A kinase (PRKA) anchor protein 11
chr11_-_75454656 3.462 ENSMUST00000173320.1
 Wdr81
WD repeat domain 81
chr3_-_108086590 3.412 ENSMUST00000102638.1
ENSMUST00000102637.1
 Ampd2

adenosine monophosphate deaminase 2

chrX_-_51681703 3.397 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr1_+_181352618 3.338 ENSMUST00000161880.1
ENSMUST00000027795.7
 Cnih3

cornichon homolog 3 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 284 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.7 GO:0008643 carbohydrate transport(GO:0008643)
0.4 10.2 GO:0021859 pyramidal neuron differentiation(GO:0021859)
1.3 9.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 8.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 7.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 7.1 GO:0007224 smoothened signaling pathway(GO:0007224)
0.2 6.3 GO:0097352 autophagosome maturation(GO:0097352)
1.9 5.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.9 5.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
1.1 5.4 GO:0097167 circadian regulation of translation(GO:0097167)
0.9 4.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.5 4.6 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 4.6 GO:1902476 chloride transmembrane transport(GO:1902476)
1.1 4.5 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.3 4.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 4.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.6 3.9 GO:0003383 apical constriction(GO:0003383)
0.6 3.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.0 3.8 GO:0070829 heterochromatin maintenance(GO:0070829)
0.5 3.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 GO:0090544 BAF-type complex(GO:0090544)
0.0 8.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 6.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 6.4 GO:0030426 growth cone(GO:0030426)
1.1 5.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 5.5 GO:0000139 Golgi membrane(GO:0000139)
0.6 5.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 4.8 GO:0071141 SMAD protein complex(GO:0071141)
0.3 4.6 GO:0043203 axon hillock(GO:0043203)
0.0 4.6 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6 4.2 GO:0033263 CORVET complex(GO:0033263)
0.2 4.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 4.0 GO:1990635 proximal dendrite(GO:1990635)
0.2 3.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 3.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 3.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 3.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.4 3.4 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
2.1 8.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 8.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 7.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 7.5 GO:0051018 protein kinase A binding(GO:0051018)
0.7 6.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 6.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 6.3 GO:0015485 cholesterol binding(GO:0015485)
0.3 6.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 6.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 5.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 5.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.9 GO:0008017 microtubule binding(GO:0008017)
0.0 4.7 GO:0030674 protein binding, bridging(GO:0030674)
1.5 4.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.5 4.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 4.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 4.2 GO:0097109 neuroligin family protein binding(GO:0097109)
1.3 3.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 7.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 5.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 5.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 5.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 3.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 2.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 2.5 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.8 PID_S1P_S1P3_PATHWAY S1P3 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 7.9 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 5.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 5.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 4.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.3 4.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 4.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.7 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 3.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 3.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 3.0 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.9 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 2.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling