Motif ID: Msx2_Hoxd4

Z-value: 1.138

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.324.3e-02Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 15.235 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170671 9.647 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr1_-_190170178 8.440 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr2_+_4017727 7.680 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr2_-_63184253 7.579 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_+_62419668 6.707 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_-_85741389 6.201 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr6_-_36811361 6.197 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr14_-_88471396 6.101 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr3_-_49757257 5.754 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_-_163725123 5.642 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr2_-_63184170 5.156 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr1_+_165788681 4.200 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr1_+_159737510 3.947 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_62765618 3.741 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_21111452 3.448 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_+_165788746 3.370 ENSMUST00000161559.2
 Cd247
CD247 antigen
chrX_+_101640056 3.089 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr7_+_96522342 2.784 ENSMUST00000129737.1
 Tenm4
teneurin transmembrane protein 4
chr18_+_52767994 2.580 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
 Sncaip


synuclein, alpha interacting protein (synphilin)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.0 18.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 13.1 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 9.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 7.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.3 7.6 GO:0070207 protein homotrimerization(GO:0070207)
0.3 6.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
2.1 6.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 5.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 5.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.2 5.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 4.3 GO:0007416 synapse assembly(GO:0007416)
1.0 3.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 3.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 3.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.0 3.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.7 2.8 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.4 2.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 2.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 2.3 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 2.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 7.9 GO:0031594 neuromuscular junction(GO:0031594)
1.9 7.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 7.5 GO:0005923 bicellular tight junction(GO:0005923)
1.3 3.9 GO:0072534 perineuronal net(GO:0072534)
0.0 3.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.7 GO:0016607 nuclear speck(GO:0016607)
0.2 3.4 GO:0042588 zymogen granule(GO:0042588)
0.0 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.2 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.8 GO:0071564 npBAF complex(GO:0071564)
0.1 1.7 GO:0044327 dendritic spine head(GO:0044327)
0.2 1.5 GO:0071439 clathrin complex(GO:0071439)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.3 1.0 GO:0055087 Ski complex(GO:0055087)
0.2 0.9 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.5 18.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 17.5 GO:0005509 calcium ion binding(GO:0005509)
0.6 12.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 7.7 GO:0030674 protein binding, bridging(GO:0030674)
0.1 7.6 GO:1990782 protein tyrosine kinase binding(GO:1990782)
2.1 6.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 5.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 4.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 4.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 3.9 GO:0046625 sphingolipid binding(GO:0046625)
0.5 3.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.0 3.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 2.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 7.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.4 6.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 4.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.6 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_S1P_S1P3_PATHWAY S1P3 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 12.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.3 7.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways