Motif ID: Msx3

Z-value: 0.364


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049083_140049089-0.552.0e-04Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 69 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_53975246 1.772 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr2_-_45117349 1.011 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr10_+_81257277 0.931 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr1_-_158356258 0.896 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_39612934 0.878 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr2_-_33087169 0.802 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr13_+_83732438 0.730 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr4_+_102254739 0.727 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_33086366 0.683 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr5_+_14514918 0.668 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr18_+_57468478 0.666 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr17_+_21383725 0.651 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr15_+_44787746 0.646 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chrX_-_143933204 0.645 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 0.638 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_+_82252397 0.626 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr5_-_62766153 0.611 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_125136692 0.600 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr9_-_15301555 0.579 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr7_+_103550368 0.547 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.9 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.8 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.7 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 0.7 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.5 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.4 GO:0042701 progesterone secretion(GO:0042701)
0.1 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.7 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 0.7 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.5 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.3 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling