Motif ID: Myb

Z-value: 2.010


Transcription factors associated with Myb:

Gene SymbolEntrez IDGene Name
Myb ENSMUSG00000019982.8 Myb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybmm10_v2_chr10_-_21160925_211609840.846.6e-12Click!


Activity profile for motif Myb.

activity profile for motif Myb


Sorted Z-values histogram for motif Myb

Sorted Z-values for motif Myb



Network of associatons between targets according to the STRING database.



First level regulatory network of Myb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_60925612 14.610 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr2_+_118814237 11.459 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr11_-_69921057 11.289 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr4_-_118437331 11.258 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_+_118814195 10.784 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr11_-_69920892 10.495 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr10_+_84838143 10.273 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr2_+_118813995 9.778 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr16_-_46496955 9.599 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr2_-_127831817 8.556 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr14_-_54577578 8.360 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr9_+_106281061 8.358 ENSMUST00000072206.6
 Poc1a
POC1 centriolar protein homolog A (Chlamydomonas)
chr14_+_46760526 8.282 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr6_+_124829540 8.187 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr19_+_36409719 8.169 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr2_-_37703275 8.034 ENSMUST00000072186.5
 Strbp
spermatid perinuclear RNA binding protein
chr17_-_70851189 7.917 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_69921329 7.883 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
 Eif5a


eukaryotic translation initiation factor 5A


chr6_+_124829582 7.774 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr10_-_95564167 7.516 ENSMUST00000020217.5
 Nudt4
nudix (nucleoside diphosphate linked moiety X)-type motif 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 37.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
2.0 36.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.3 17.2 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
1.0 16.3 GO:0030953 astral microtubule organization(GO:0030953)
0.1 16.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.8 13.2 GO:0070986 left/right axis specification(GO:0070986)
1.0 11.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
1.6 11.3 GO:0000279 M phase(GO:0000279)
3.6 10.9 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
2.1 10.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
2.0 10.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 9.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 8.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.9 8.6 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.4 8.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.4 8.4 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
1.2 8.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.0 8.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 8.0 GO:0007638 mechanosensory behavior(GO:0007638)
1.3 7.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 37.5 GO:0005642 annulate lamellae(GO:0005642)
0.9 32.0 GO:0035371 microtubule plus-end(GO:0035371)
5.9 17.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 17.1 GO:0005813 centrosome(GO:0005813)
0.2 15.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 14.1 GO:0005882 intermediate filament(GO:0005882)
0.0 13.3 GO:0005730 nucleolus(GO:0005730)
0.2 12.2 GO:0005871 kinesin complex(GO:0005871)
0.1 11.3 GO:0000922 spindle pole(GO:0000922)
0.6 10.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 10.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 10.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 10.4 GO:0000776 kinetochore(GO:0000776)
0.1 9.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
2.1 8.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 8.5 GO:0031519 PcG protein complex(GO:0031519)
0.1 8.5 GO:0005643 nuclear pore(GO:0005643)
0.4 8.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 8.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 8.2 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 37.1 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 17.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 12.2 GO:0003777 microtubule motor activity(GO:0003777)
1.9 11.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 10.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 10.5 GO:0017025 TBP-class protein binding(GO:0017025)
2.6 10.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.6 8.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 8.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 8.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 8.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 8.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 7.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 7.9 GO:0003725 double-stranded RNA binding(GO:0003725)
1.3 7.5 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.4 7.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.7 6.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.2 6.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 6.2 GO:0042393 histone binding(GO:0042393)
0.1 6.0 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 40.2 PID_PLK1_PATHWAY PLK1 signaling events
0.4 27.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.8 17.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 17.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 16.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 8.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 7.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.0 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 4.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 4.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.0 PID_ATM_PATHWAY ATM pathway
0.2 2.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 39.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.4 37.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.7 18.7 REACTOME_KINESINS Genes involved in Kinesins
0.5 18.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.7 17.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.6 15.0 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1 11.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 10.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 10.0 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 9.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 9.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 7.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 7.7 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 7.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.8 6.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 5.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.4 5.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 4.6 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 4.4 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 4.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC