Motif ID: Mybl1

Z-value: 1.759


Transcription factors associated with Mybl1:

Gene SymbolEntrez IDGene Name
Mybl1 ENSMUSG00000025912.10 Mybl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl1mm10_v2_chr1_-_9700209_97003290.278.3e-02Click!


Activity profile for motif Mybl1.

activity profile for motif Mybl1


Sorted Z-values histogram for motif Mybl1

Sorted Z-values for motif Mybl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_94172618 16.369 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr15_-_88978958 10.031 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr5_+_75075464 9.890 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr2_+_118814237 9.148 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_118814195 8.765 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 8.546 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr14_+_46760526 8.331 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr9_+_78191966 8.081 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr3_+_137623672 8.021 ENSMUST00000053855.7
 Ddit4l
DNA-damage-inducible transcript 4-like
chr7_+_126862431 7.322 ENSMUST00000132808.1
 Hirip3
HIRA interacting protein 3
chr11_-_106999369 7.180 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr11_-_69921190 7.159 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr4_-_118437331 7.134 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr9_+_7764041 6.929 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr3_+_145758674 6.729 ENSMUST00000029845.8
 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr14_-_20181773 6.659 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr6_+_124829540 6.569 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr3_+_137624031 6.225 ENSMUST00000165845.1
 Ddit4l
DNA-damage-inducible transcript 4-like
chr6_+_124829582 6.187 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr12_+_112146187 6.155 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 26.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
3.7 21.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
2.3 16.4 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7 16.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
2.5 12.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.4 12.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 10.0 GO:0071397 cellular response to cholesterol(GO:0071397)
0.7 9.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527) forebrain dorsal/ventral pattern formation(GO:0021798)
2.5 9.8 GO:0003360 brainstem development(GO:0003360)
0.2 8.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.4 8.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 7.9 GO:0044458 motile cilium assembly(GO:0044458)
0.5 7.6 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.9 7.5 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 7.2 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
1.0 7.1 GO:0000279 M phase(GO:0000279)
0.0 7.0 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.7 6.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 6.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.2 6.2 GO:0019659 fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 31.0 GO:0035371 microtubule plus-end(GO:0035371)
2.0 21.7 GO:0005642 annulate lamellae(GO:0005642)
0.2 17.3 GO:0005643 nuclear pore(GO:0005643)
0.6 15.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 14.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 12.2 GO:0005681 spliceosomal complex(GO:0005681)
0.1 12.0 GO:0005901 caveola(GO:0005901)
0.4 11.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 10.1 GO:0005871 kinesin complex(GO:0005871)
3.3 9.8 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 9.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 6.6 GO:0000776 kinetochore(GO:0000776)
0.0 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 5.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 5.7 GO:0035861 site of double-strand break(GO:0035861)
0.2 5.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.6 4.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 4.7 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 21.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.5 15.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 13.7 GO:0003735 structural constituent of ribosome(GO:0003735)
4.2 12.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 10.7 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 10.4 GO:0008565 protein transporter activity(GO:0008565)
1.6 9.8 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 8.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 8.0 GO:0008201 heparin binding(GO:0008201)
1.6 7.9 GO:0032027 myosin light chain binding(GO:0032027)
0.2 7.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 7.3 GO:0070491 repressing transcription factor binding(GO:0070491)
1.2 7.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.1 6.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 6.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 6.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.2 5.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 5.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 5.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 5.2 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 14.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 10.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 8.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 4.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 4.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 4.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 3.6 PID_ATR_PATHWAY ATR signaling pathway
0.1 3.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 1.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.7 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 21.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 21.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 14.9 REACTOME_KINESINS Genes involved in Kinesins
0.2 14.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 12.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.6 9.9 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 8.3 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.3 8.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 7.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.4 7.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 6.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 6.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 6.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.0 5.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 5.9 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 5.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 5.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 4.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 4.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
1.2 4.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation