Motif ID: Mybl2

Z-value: 1.439


Transcription factors associated with Mybl2:

Gene SymbolEntrez IDGene Name
Mybl2 ENSMUSG00000017861.5 Mybl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2mm10_v2_chr2_+_163054682_1630546930.712.5e-07Click!


Activity profile for motif Mybl2.

activity profile for motif Mybl2


Sorted Z-values histogram for motif Mybl2

Sorted Z-values for motif Mybl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_13573927 9.439 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr1_-_169531343 7.528 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_-_106999369 6.947 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr19_-_41802028 6.737 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
 Arhgap19


Rho GTPase activating protein 19


chr1_-_169531447 6.376 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr10_+_84838143 6.327 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr9_-_79977782 6.097 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr4_-_124936852 5.547 ENSMUST00000030690.5
ENSMUST00000084296.3
 Cdca8

cell division cycle associated 8

chr11_-_90002881 5.493 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr11_-_106999482 5.362 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr5_-_77095225 5.306 ENSMUST00000120827.2
ENSMUST00000113453.2
 Hopx

HOP homeobox

chr13_+_51645232 5.177 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr4_-_116627921 4.967 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr13_-_23551648 4.917 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr1_+_191821444 4.719 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr2_+_25372315 4.610 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr1_+_57995971 4.591 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr14_-_67715585 4.129 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr4_-_41695935 4.117 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr8_+_83715504 4.074 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.8 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.5 11.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 9.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.9 9.4 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.5 8.8 GO:0072584 caveolin-mediated endocytosis(GO:0072584)
0.1 7.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 6.9 GO:0007099 centriole replication(GO:0007099)
0.8 6.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 6.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.3 6.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.3 5.7 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 5.6 GO:0006413 translational initiation(GO:0006413)
0.1 5.5 GO:0015914 phospholipid transport(GO:0015914)
0.9 5.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.4 5.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 5.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.3 5.1 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.1 4.4 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
1.0 4.1 GO:0003360 brainstem development(GO:0003360)
0.8 4.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 16.9 GO:0031262 Ndc80 complex(GO:0031262)
0.0 13.6 GO:0005730 nucleolus(GO:0005730)
0.2 12.9 GO:0005643 nuclear pore(GO:0005643)
2.4 9.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 8.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 7.3 GO:0005681 spliceosomal complex(GO:0005681)
0.5 6.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 6.6 GO:0005871 kinesin complex(GO:0005871)
0.2 6.5 GO:0000788 nuclear nucleosome(GO:0000788)
1.1 5.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 5.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 5.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 4.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 4.4 GO:0005682 U5 snRNP(GO:0005682)
0.2 4.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.4 4.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.6 4.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 4.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 4.0 GO:0005769 early endosome(GO:0005769)
0.0 4.0 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
2.4 9.4 GO:1990254 keratin filament binding(GO:1990254)
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.2 7.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 7.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 7.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
1.0 6.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 6.6 GO:0003777 microtubule motor activity(GO:0003777)
0.5 5.5 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
1.3 5.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 4.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 4.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 3.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 3.7 GO:0019902 phosphatase binding(GO:0019902)
0.1 3.6 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.9 3.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 3.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 3.4 GO:0005080 protein kinase C binding(GO:0005080)
0.8 3.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
1.0 3.1 GO:0051870 methotrexate binding(GO:0051870)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 12.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 7.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 5.7 PID_ATM_PATHWAY ATM pathway
0.1 5.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 3.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 30.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 13.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 11.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 9.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 9.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 6.6 REACTOME_KINESINS Genes involved in Kinesins
0.3 5.5 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 5.0 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 4.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 4.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 3.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 3.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 2.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.3 2.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA