Motif ID: Myog_Tcf12

Z-value: 1.231

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111651_72111712-0.278.2e-02Click!


Activity profile for motif Myog_Tcf12.

activity profile for motif Myog_Tcf12


Sorted Z-values histogram for motif Myog_Tcf12

Sorted Z-values for motif Myog_Tcf12



Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 10.842 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr16_+_91269759 10.508 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr8_+_94152607 10.332 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr4_-_64046925 9.351 ENSMUST00000107377.3
 Tnc
tenascin C
chr2_-_71546745 8.600 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr5_+_75075464 8.106 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr16_-_22439719 8.096 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr5_-_135251209 7.501 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr12_-_119238794 7.476 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr2_+_70562007 7.115 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr7_+_19094594 6.723 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr16_-_22439570 6.653 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr2_-_122611238 6.546 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_+_57133065 6.365 ENSMUST00000075770.6
 Megf10
multiple EGF-like-domains 10
chr12_+_108334341 6.344 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr11_+_117809653 6.205 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr7_+_4119556 6.136 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr7_+_4119525 6.118 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr11_+_115163333 5.997 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr13_-_60177357 5.990 ENSMUST00000065086.4
 Gas1
growth arrest specific 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 286 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 16.7 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
3.3 16.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.1 16.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.3 12.6 GO:1902476 chloride transmembrane transport(GO:1902476)
2.7 10.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.8 10.5 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
3.4 10.3 GO:0097212 lysosomal membrane organization(GO:0097212)
0.8 10.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
2.3 9.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.8 9.0 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.9 8.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 8.5 GO:0048663 neuron fate commitment(GO:0048663)
2.5 7.5 GO:1990523 bone regeneration(GO:1990523)
0.4 7.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.6 6.7 GO:0014842 skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842)
2.2 6.5 GO:0006601 creatine biosynthetic process(GO:0006601)
1.1 6.4 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.7 6.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.6 6.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 6.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 12.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.5 10.7 GO:0001891 phagocytic cup(GO:0001891)
0.3 10.6 GO:0060077 inhibitory synapse(GO:0060077)
0.7 9.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 8.8 GO:0009986 cell surface(GO:0009986)
0.5 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.7 8.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 8.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 7.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 7.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 7.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 7.1 GO:0005884 actin filament(GO:0005884)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
2.1 6.4 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
1.2 6.0 GO:0097149 centralspindlin complex(GO:0097149)
0.5 5.8 GO:0032426 stereocilium tip(GO:0032426)
0.2 5.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 4.8 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 13.2 GO:0008307 structural constituent of muscle(GO:0008307)
1.8 12.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.1 12.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.8 12.3 GO:0001849 complement component C1q binding(GO:0001849)
0.1 10.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 9.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.6 9.4 GO:0045545 syndecan binding(GO:0045545)
0.0 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.8 9.1 GO:0042289 MHC class II protein binding(GO:0042289)
1.8 9.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.7 8.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 7.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 7.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 6.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 6.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 6.0 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 5.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 5.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.5 5.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.5 14.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 12.5 PID_CDC42_PATHWAY CDC42 signaling events
0.2 10.8 NABA_COLLAGENS Genes encoding collagen proteins
0.3 7.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 7.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 6.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 6.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 6.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 4.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.4 2.6 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 12.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 10.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 9.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 7.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 7.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 6.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.8 5.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 5.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 5.5 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 5.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 5.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 4.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 4.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)