Motif ID: Mzf1

Z-value: 0.964


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13054665_13054764-0.143.9e-01Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.824 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_139543889 5.024 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr11_-_100759942 3.784 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_+_28142267 3.163 ENSMUST00000043503.3
 Scube3
signal peptide, CUB domain, EGF-like 3
chr1_+_167001457 3.092 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr4_-_68954351 3.037 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr7_-_34812677 2.897 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr11_-_100759740 2.782 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr3_+_96596628 2.676 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr10_-_109010955 2.629 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr2_+_121295437 2.551 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr1_+_66321708 2.518 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr11_+_70018421 2.443 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr10_-_114801364 2.380 ENSMUST00000061632.7
 Trhde
TRH-degrading enzyme
chr9_-_97018823 2.348 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr9_+_119402444 2.305 ENSMUST00000035093.8
ENSMUST00000165044.1
 Acvr2b

activin receptor IIB

chr1_+_167001417 2.303 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr11_+_105589970 2.289 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr11_+_70018728 2.262 ENSMUST00000018700.6
ENSMUST00000134376.2
 Dlg4

discs, large homolog 4 (Drosophila)

chr1_-_138842429 2.165 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 284 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.2 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 6.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.0 5.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 4.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 4.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.8 3.8 GO:0015671 oxygen transport(GO:0015671)
0.7 3.7 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.3 3.6 GO:0042711 maternal behavior(GO:0042711)
0.3 3.3 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.2 3.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 3.0 GO:0050821 protein stabilization(GO:0050821)
0.2 2.9 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.2 2.9 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 2.9 GO:0016486 peptide hormone processing(GO:0016486)
0.7 2.8 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 2.8 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.4 2.6 GO:1902302 regulation of potassium ion export(GO:1902302)
0.3 2.6 GO:0005513 detection of calcium ion(GO:0005513)
0.3 2.6 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.1 2.6 GO:1900452 regulation of long term synaptic depression(GO:1900452)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 8.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 5.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.2 GO:0030427 site of polarized growth(GO:0030427)
0.1 4.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 3.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.9 GO:0035861 site of double-strand break(GO:0035861)
0.3 2.8 GO:0005833 hemoglobin complex(GO:0005833)
0.3 2.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.5 GO:0097060 synaptic membrane(GO:0097060)
0.2 2.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 2.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 2.1 GO:0070822 Sin3-type complex(GO:0070822)
0.1 2.1 GO:0071565 nBAF complex(GO:0071565)
0.1 2.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.0 GO:0031045 dense core granule(GO:0031045)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 2.0 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0005096 GTPase activator activity(GO:0005096)
1.0 8.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 4.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 3.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.8 3.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 3.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 3.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 3.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 2.9 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.5 2.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.9 2.8 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.7 GO:0030507 spectrin binding(GO:0030507)
0.7 2.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 2.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.3 2.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 5.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 1.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.1 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.0 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 3.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 2.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 2.1 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 1.9 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.9 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.5 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions