Motif ID: Nanog

Z-value: 0.554


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.182.6e-01Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 3.531 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chrY_-_1245685 1.915 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr18_-_78206408 1.583 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr13_-_41273977 1.358 ENSMUST00000163881.1
Gm17364
predicted gene, 17364
chr15_-_71954395 1.013 ENSMUST00000159410.1
Col22a1
collagen, type XXII, alpha 1
chr2_+_20737306 0.962 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr10_+_58394381 0.870 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr18_+_57142782 0.841 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chrX_+_153237466 0.831 ENSMUST00000143880.1
Klf8
Kruppel-like factor 8
chr13_-_51567084 0.796 ENSMUST00000021898.5
Shc3
src homology 2 domain-containing transforming protein C3
chr10_-_42583628 0.752 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr15_-_66831625 0.740 ENSMUST00000164163.1
Sla
src-like adaptor
chr10_+_58394361 0.722 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr8_-_89044162 0.685 ENSMUST00000034090.6
Sall1
sal-like 1 (Drosophila)
chr7_-_115846080 0.646 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr3_+_68869563 0.626 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr2_+_62664279 0.612 ENSMUST00000028257.2
Gca
grancalcin
chrX_-_135009185 0.598 ENSMUST00000113185.2
ENSMUST00000064659.5
Zmat1

zinc finger, matrin type 1

chr12_+_108334341 0.591 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr19_-_36736653 0.563 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.5 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 1.9 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.5 1.6 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 1.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 0.8 GO:0021764 amygdala development(GO:0021764)
0.1 0.8 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.0 0.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 0.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.6 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.6 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 0.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.6 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.6 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.2 0.5 GO:0006553 lysine metabolic process(GO:0006553)
0.1 0.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.5 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.5 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.0 0.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.9 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.6 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 1.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.6 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.3 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling