Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.569

Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:

Gene SymbolEntrez IDGene Name
Bhlha15 ENSMUSG00000052271.7 Bhlha15
Bhlhe22 ENSMUSG00000025128.6 Bhlhe22
Neurod2 ENSMUSG00000038255.6 Neurod2
Olig1 ENSMUSG00000046160.5 Olig1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe22mm10_v2_chr3_+_18054258_180543250.594.6e-05Click!
Neurod2mm10_v2_chr11_-_98329641_983296540.551.8e-04Click!
Olig1mm10_v2_chr16_+_91269759_91269778-0.086.2e-01Click!


Activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1.

activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1


Sorted Z-values histogram for motif Neurod2_Bhlha15_Bhlhe22_Olig1

Sorted Z-values for motif Neurod2_Bhlha15_Bhlhe22_Olig1



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_43235856 3.793 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr17_-_36989504 3.417 ENSMUST00000169189.1
 H2-M5
histocompatibility 2, M region locus 5
chr3_-_120886691 2.762 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr5_+_124194894 2.604 ENSMUST00000159053.1
ENSMUST00000162577.1
 Gm16338

predicted gene 16338

chr10_-_25200110 2.322 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr1_-_111864869 2.112 ENSMUST00000035462.5
 Dsel
dermatan sulfate epimerase-like
chr1_-_150392719 2.040 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
 BC003331


cDNA sequence BC003331


chr1_+_177444653 1.984 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr4_-_42034726 1.889 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr5_-_66618772 1.791 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
 Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr4_-_141598206 1.747 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr5_-_66618636 1.733 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
 Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr1_+_15287259 1.730 ENSMUST00000175681.1
 Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr2_+_65930117 1.660 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_69670100 1.612 ENSMUST00000100050.3
 Klhl41
kelch-like 41
chr2_-_79456750 1.571 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr9_+_72985568 1.435 ENSMUST00000150826.2
ENSMUST00000085350.4
ENSMUST00000140675.1
 Ccpg1


cell cycle progression 1


chr9_-_21918089 1.433 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
 Rab3d



RAB3D, member RAS oncogene family



chr19_-_37176055 1.383 ENSMUST00000142973.1
ENSMUST00000154376.1
 Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr1_-_44218952 1.338 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.8 3.3 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 3.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 3.3 GO:0021766 hippocampus development(GO:0021766)
0.0 3.3 GO:0050821 protein stabilization(GO:0050821)
0.4 2.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 2.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.1 1.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 1.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 1.6 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 1.4 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.3 1.4 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 1.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 1.3 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 1.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.3 GO:0070914 nucleosome disassembly(GO:0006337) UV-damage excision repair(GO:0070914)
0.0 1.1 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.1 1.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.6 GO:0097441 basilar dendrite(GO:0097441)
0.1 3.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.9 GO:0031430 M band(GO:0031430)
0.1 2.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.4 GO:0042588 zymogen granule(GO:0042588)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.2 1.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.2 0.9 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.8 GO:0001739 sex chromatin(GO:0001739)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.7 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.1 0.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.4 GO:0042605 peptide antigen binding(GO:0042605)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 2.3 GO:0016208 AMP binding(GO:0016208)
0.1 2.3 GO:0070888 E-box binding(GO:0070888)
0.1 2.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.7 GO:0031005 filamin binding(GO:0031005)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.1 0.9 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1