Motif ID: Nfat5

Z-value: 0.868


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293500_1072935590.509.3e-04Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 6.844 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr7_+_99535652 4.626 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr4_-_82505707 4.337 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr7_+_99535439 3.632 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr4_-_82505749 3.539 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr10_-_95415484 3.208 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr2_+_68117713 3.158 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr7_-_97417730 3.155 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr5_-_104021919 3.135 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr14_-_101609033 3.016 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr6_-_142964404 2.987 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr18_+_36559972 2.748 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr5_-_104021799 2.687 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr10_-_95415283 2.615 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr14_+_17660956 2.238 ENSMUST00000022303.7
ENSMUST00000091471.4
 Thrb

thyroid hormone receptor beta

chr12_+_102948843 2.237 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr5_-_148392810 2.214 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_-_138396438 2.066 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr6_+_120773633 2.022 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr15_-_98881255 1.927 ENSMUST00000024518.9
 Rhebl1
Ras homolog enriched in brain like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
2.0 7.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 6.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 6.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
1.5 5.8 GO:0006710 androgen catabolic process(GO:0006710)
0.3 5.8 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.5 3.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.4 3.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 3.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.3 3.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 3.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 3.0 GO:0030048 actin filament-based movement(GO:0030048)
0.1 2.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 2.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.7 2.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.2 2.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 2.2 GO:0015809 arginine transport(GO:0015809)
0.3 1.9 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 1.9 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 1.9 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.3 GO:0031143 pseudopodium(GO:0031143)
0.4 7.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 7.7 GO:0005811 lipid particle(GO:0005811)
0.1 6.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.1 GO:0000139 Golgi membrane(GO:0000139)
0.2 2.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.3 1.6 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.7 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 7.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 6.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 6.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
1.2 5.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.8 5.8 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.9 3.5 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.8 3.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.5 3.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 3.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 2.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 2.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.4 2.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.3 2.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 1.9 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 1.8 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 5.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 4.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.5 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.9 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 8.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 6.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 5.8 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 3.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 1.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.4 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 1.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.2 0.7 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway