Motif ID: Nfatc1

Z-value: 5.582


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80708115_80708180-0.105.2e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 196.649 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 194.922 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 179.138 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 175.385 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 169.404 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 164.275 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 153.209 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 151.574 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 147.669 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3017408 144.729 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3005125 140.642 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr14_-_19418930 125.252 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 121.765 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 119.655 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 110.206 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 95.346 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chrX_+_103422010 20.129 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr3_-_145649970 16.951 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr10_+_4611971 13.634 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr11_+_112782182 10.818 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1145.5 GO:0008150 biological_process(GO:0008150)
3.4 17.0 GO:0060591 chondroblast differentiation(GO:0060591)
2.0 16.3 GO:0072615 interleukin-17 secretion(GO:0072615)
2.3 16.2 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
4.5 13.6 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
3.6 10.8 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.8 9.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.9 9.4 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.9 8.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.5 8.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.3 7.8 GO:1904587 response to glycoprotein(GO:1904587)
0.7 5.8 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 5.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 5.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.7 4.7 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.8 4.5 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
1.5 4.4 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.9 4.3 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.5 4.2 GO:0048251 elastic fiber assembly(GO:0048251)
1.0 4.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1274.7 GO:0005575 cellular_component(GO:0005575)
0.1 17.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 14.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.4 9.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.6 8.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.1 5.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 5.2 GO:0005614 interstitial matrix(GO:0005614)
1.5 4.4 GO:0071914 prominosome(GO:0071914)
0.3 4.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 4.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.5 3.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 3.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.4 GO:0034451 centriolar satellite(GO:0034451)
0.8 3.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 3.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 3.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.5 2.8 GO:0045179 apical cortex(GO:0045179)
0.2 2.7 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1226.7 GO:0003674 molecular_function(GO:0003674)
4.1 16.3 GO:0008142 oxysterol binding(GO:0008142)
0.7 15.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
4.5 13.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.1 11.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 10.6 GO:0042805 actinin binding(GO:0042805)
1.9 9.4 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.1 8.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.7 7.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.8 7.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.7 6.7 GO:0042609 CD4 receptor binding(GO:0042609)
1.9 5.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.4 5.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 5.3 GO:0030332 cyclin binding(GO:0030332)
0.9 5.1 GO:0043426 MRF binding(GO:0043426)
0.9 4.5 GO:0005534 galactose binding(GO:0005534)
1.1 4.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.6 4.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.2 3.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.8 3.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 29.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 18.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
1.2 17.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 11.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.3 8.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 7.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 6.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 5.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.6 4.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 3.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 31.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 16.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 9.4 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
2.6 7.8 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 5.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 5.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 4.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 4.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.6 3.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.4 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 3.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 3.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 3.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 1.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA