Motif ID: Nfatc2

Z-value: 1.568


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168590315_1685903720.134.2e-01Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 10.830 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_+_3000922 10.458 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 9.095 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 8.780 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 8.651 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 8.636 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 8.028 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3017408 7.816 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3036877 7.472 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr2_+_98662227 7.260 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr9_+_3034599 7.161 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 7.121 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_-_98667264 7.104 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3015654 6.939 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3005125 6.868 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chrX_+_103422010 6.832 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_5796924 6.525 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr9_+_3018753 6.036 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 5.912 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr14_+_75955003 5.596 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 311 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.2 11.0 GO:0035063 nuclear speck organization(GO:0035063)
0.3 9.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 8.0 GO:0007416 synapse assembly(GO:0007416)
0.4 6.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 5.5 GO:0021860 pyramidal neuron development(GO:0021860)
1.3 5.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.1 4.4 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.7 4.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.5 3.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.8 3.8 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.5 3.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 3.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.4 3.6 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 3.6 GO:0042118 endothelial cell activation(GO:0042118)
0.3 3.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 3.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.5 3.4 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.8 3.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 3.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 11.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.7 GO:0014704 intercalated disc(GO:0014704)
0.2 6.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 5.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 5.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 5.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 4.9 GO:0043197 dendritic spine(GO:0043197)
0.1 4.4 GO:0043194 axon initial segment(GO:0043194)
0.3 4.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 3.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.4 GO:0071565 nBAF complex(GO:0071565)
0.2 3.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 3.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.2 GO:0055037 recycling endosome(GO:0055037)
0.4 3.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.3 3.0 GO:0071439 clathrin complex(GO:0071439)
0.2 3.0 GO:0031143 pseudopodium(GO:0031143)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 2.8 GO:0044307 dendritic branch(GO:0044307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.6 GO:0008017 microtubule binding(GO:0008017)
0.3 5.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 4.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.7 4.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 4.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 4.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 4.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 4.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.6 3.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.9 3.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.3 3.5 GO:0050897 cobalt ion binding(GO:0050897)
0.8 3.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 3.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 3.1 GO:0050693 LBD domain binding(GO:0050693)
0.3 3.0 GO:0005523 tropomyosin binding(GO:0005523)
0.2 3.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 3.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 2.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 2.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 4.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 4.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.5 3.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.3 2.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 2.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 1.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.3 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 7.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 5.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 3.7 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.3 3.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 3.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 2.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 2.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.3 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 2.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.8 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein