Motif ID: Nfatc3

Z-value: 1.183


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.287.2e-02Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 4.894 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr18_-_80713062 3.295 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr10_+_4611971 3.273 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_-_97584605 2.626 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_-_16575456 2.559 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr4_-_97584612 2.551 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_136875794 1.997 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr3_-_86548268 1.867 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr2_+_3114220 1.819 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr11_+_63133068 1.797 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr5_-_88527841 1.796 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr7_-_49636847 1.676 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr2_+_157560078 1.665 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
 Nnat







neuronatin







chr3_-_61365951 1.604 ENSMUST00000066298.2
 B430305J03Rik
RIKEN cDNA B430305J03 gene
chr3_-_37125943 1.590 ENSMUST00000029275.5
 Il2
interleukin 2
chr13_+_31806627 1.519 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr6_+_48841476 1.514 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 1.508 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr16_-_22161450 1.487 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_100494044 1.459 ENSMUST00000153287.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.8 4.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 3.8 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
1.1 3.3 GO:0060854 patterning of lymph vessels(GO:0060854)
0.8 3.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 3.1 GO:0032060 bleb assembly(GO:0032060)
0.3 2.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.5 2.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.5 2.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 2.3 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.5 1.8 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.6 1.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 1.6 GO:0051451 myoblast migration(GO:0051451)
0.5 1.5 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.5 1.4 GO:1903903 striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903)
0.3 1.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.4 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 1.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 1.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 3.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 3.1 GO:0043218 compact myelin(GO:0043218)
0.1 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.0 GO:0043209 myelin sheath(GO:0043209)
0.1 1.7 GO:0000242 pericentriolar material(GO:0000242)
0.2 1.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 1.4 GO:0030478 actin cap(GO:0030478)
0.1 1.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.3 GO:0031143 pseudopodium(GO:0031143)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.0 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
1.1 3.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 2.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 2.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 2.4 GO:0001972 retinoic acid binding(GO:0001972)
0.1 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.1 GO:0030246 carbohydrate binding(GO:0030246)
0.5 2.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 1.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 1.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.7 GO:0008432 JUN kinase binding(GO:0008432)
0.3 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.4 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.0 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.4 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 3.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 1.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.5 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 1.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1