Motif ID: Nfe2_Bach1_Mafk

Z-value: 0.845

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bach1mm10_v2_chr16_+_87698904_876989590.371.7e-02Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.333.4e-02Click!
Mafkmm10_v2_chr5_+_139791513_1397915390.153.6e-01Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 7.822 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 6.147 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr3_+_123267445 4.431 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_+_136713444 3.082 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr2_+_155775333 2.595 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr5_-_139484420 2.480 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr13_-_54611332 2.433 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr5_-_139484475 2.429 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr13_-_54611274 2.230 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chrX_-_103186618 2.194 ENSMUST00000121720.1
 Nap1l2
nucleosome assembly protein 1-like 2
chr9_-_86695897 2.054 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_146852359 2.029 ENSMUST00000038090.5
ENSMUST00000170055.1
 Ttll7

tubulin tyrosine ligase-like family, member 7

chr16_+_17561885 2.007 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr6_+_5725812 1.967 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr17_-_56133817 1.889 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr2_+_156475803 1.851 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chrX_+_163911401 1.808 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_156475844 1.757 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr1_-_134235420 1.723 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chrX_+_6047453 1.637 ENSMUST00000103007.3
 Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.8 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 6.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.4 5.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.3 4.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 3.7 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 3.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.4 3.1 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.4 2.6 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 2.6 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.3 2.5 GO:0005513 detection of calcium ion(GO:0005513)
0.3 2.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 2.1 GO:0035617 stress granule disassembly(GO:0035617)
0.4 2.1 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.0 2.1 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.2 2.0 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 2.0 GO:0033198 response to ATP(GO:0033198)
0.2 1.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.6 1.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.3 1.6 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 9.8 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.4 4.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 4.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 3.6 GO:0071565 nBAF complex(GO:0071565)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.8 3.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 3.0 GO:0005604 basement membrane(GO:0005604)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.7 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)
0.4 1.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.5 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 6.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 5.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.4 4.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 4.4 GO:0000149 SNARE binding(GO:0000149)
0.0 3.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.7 2.1 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.5 2.0 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 2.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.3 1.6 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.9 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 2.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.2 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 6.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 4.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 4.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 3.1 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 2.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 2.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 1.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.4 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions