Motif ID: Nfe2l1_Mafg

Z-value: 1.127

Transcription factors associated with Nfe2l1_Mafg:

Gene SymbolEntrez IDGene Name
Mafg ENSMUSG00000051510.7 Mafg
Mafg ENSMUSG00000053906.4 Mafg
Nfe2l1 ENSMUSG00000038615.11 Nfe2l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafgmm10_v2_chr11_-_120633594_120633605-0.653.9e-06Click!
Nfe2l1mm10_v2_chr11_-_96829904_96829955-0.163.2e-01Click!


Activity profile for motif Nfe2l1_Mafg.

activity profile for motif Nfe2l1_Mafg


Sorted Z-values histogram for motif Nfe2l1_Mafg

Sorted Z-values for motif Nfe2l1_Mafg



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l1_Mafg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 31.953 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 9.918 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr17_+_93199348 7.830 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr17_+_43952999 5.721 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr3_+_85915722 4.740 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr8_+_31091593 4.460 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr9_-_79977782 4.435 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr14_+_74640840 4.086 ENSMUST00000036653.3
 Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
chr2_-_112480817 3.996 ENSMUST00000099589.2
 Chrm5
cholinergic receptor, muscarinic 5
chr4_+_101507855 3.719 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr18_-_62741387 3.580 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr12_-_10900296 3.429 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_-_48432723 3.095 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr17_+_78491549 3.046 ENSMUST00000079363.4
 Gm10093
predicted pseudogene 10093
chr11_+_44617310 2.933 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr18_-_47333311 2.891 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr4_-_63403330 2.851 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr7_-_74554474 2.755 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr15_+_16778101 2.594 ENSMUST00000026432.6
 Cdh9
cadherin 9
chrX_-_141874870 2.538 ENSMUST00000182079.1
 Gm15294
predicted gene 15294

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 32.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.6 7.8 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.1 6.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.3 5.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.3 4.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.5 4.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 4.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 4.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.0 4.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.8 4.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.6 3.7 GO:0072318 clathrin coat disassembly(GO:0072318)
0.7 3.6 GO:0060467 negative regulation of fertilization(GO:0060467)
1.0 3.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 3.0 GO:0007220 Notch receptor processing(GO:0007220)
0.1 2.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.4 2.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 2.4 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.3 2.3 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.2 2.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0043195 terminal bouton(GO:0043195)
0.2 5.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 5.1 GO:0005730 nucleolus(GO:0005730)
0.3 4.1 GO:0070852 cell body fiber(GO:0070852)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 3.0 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 3.0 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.8 GO:0043196 varicosity(GO:0043196)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.6 2.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 2.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.1 GO:0070062 extracellular exosome(GO:0070062)
0.5 2.0 GO:0008623 CHRAC(GO:0008623)
0.2 1.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 1.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.7 GO:0030426 growth cone(GO:0030426)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.4 GO:0012505 endomembrane system(GO:0012505)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 34.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 14.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.5 7.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 6.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.0 5.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.9 5.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 5.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
1.5 4.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.6 4.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.4 4.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
1.3 4.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 3.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 2.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 2.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 2.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 2.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 2.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 2.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 2.2 PID_BCR_5PATHWAY BCR signaling pathway
0.1 2.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.7 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.5 4.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.5 4.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
1.4 4.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 3.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 3.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 2.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 2.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 2.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.1 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 1.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.3 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway