Motif ID: Nfia

Z-value: 1.934


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97777606_977776320.105.4e-01Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 24.400 ENSMUST00000075312.3
 Ttr
transthyretin
chr11_+_78324200 18.554 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr7_+_130936172 15.069 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr19_+_5740885 13.830 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr3_-_116129615 11.389 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr14_-_118052235 9.564 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr6_+_141524379 9.247 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr6_+_17306335 8.030 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr5_+_66968416 7.469 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr1_+_42229726 7.461 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr10_+_57784859 7.457 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr13_-_97747373 7.333 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_+_30065333 7.327 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr12_+_85473883 7.258 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr7_-_97417730 7.130 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr10_+_127725392 7.014 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr5_+_66968559 6.865 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr4_-_64046925 6.629 ENSMUST00000107377.3
 Tnc
tenascin C
chr10_+_58813359 6.613 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr10_+_4611971 6.263 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 409 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 28.7 GO:0070327 thyroid hormone transport(GO:0070327)
1.9 18.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.3 16.3 GO:0021847 ventricular zone neuroblast division(GO:0021847)
2.5 15.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
4.6 13.8 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.2 11.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
3.5 10.6 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168)
1.0 10.6 GO:0061032 visceral serous pericardium development(GO:0061032)
2.1 10.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.9 9.5 GO:0090527 actin filament reorganization(GO:0090527)
0.9 9.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.5 8.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.7 8.6 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 8.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.5 8.1 GO:0035994 response to muscle stretch(GO:0035994)
0.1 7.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.4 7.5 GO:0060134 prepulse inhibition(GO:0060134)
1.8 7.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.7 6.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012) bud outgrowth involved in lung branching(GO:0060447)
0.1 6.5 GO:0060325 face morphogenesis(GO:0060325)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 61.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 48.9 GO:0005615 extracellular space(GO:0005615)
0.0 22.9 GO:0005739 mitochondrion(GO:0005739)
0.1 13.1 GO:0005884 actin filament(GO:0005884)
0.1 11.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 10.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.8 10.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 9.9 GO:0031594 neuromuscular junction(GO:0031594)
0.3 9.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
2.2 8.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 8.8 GO:0005925 focal adhesion(GO:0005925)
0.2 8.7 GO:0002102 podosome(GO:0002102)
0.2 7.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 7.4 GO:0016363 nuclear matrix(GO:0016363)
1.2 7.1 GO:0035976 AP1 complex(GO:0035976)
0.9 6.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.4 6.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 6.0 GO:0072562 blood microparticle(GO:0072562)
1.4 5.7 GO:0014802 terminal cisterna(GO:0014802)
0.1 5.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 28.7 GO:0070324 thyroid hormone binding(GO:0070324)
3.1 18.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 14.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 14.5 GO:0005178 integrin binding(GO:0005178)
0.6 13.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.3 12.1 GO:0036122 BMP binding(GO:0036122)
0.3 11.5 GO:0070412 R-SMAD binding(GO:0070412)
2.8 11.4 GO:0008131 primary amine oxidase activity(GO:0008131)
2.8 11.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.1 10.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.2 9.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
2.3 9.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.7 9.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 7.7 GO:0019003 GDP binding(GO:0019003)
0.2 7.6 GO:0005504 fatty acid binding(GO:0005504)
0.2 6.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.7 6.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.1 6.6 GO:0045545 syndecan binding(GO:0045545)
2.2 6.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 6.4 GO:0008432 JUN kinase binding(GO:0008432)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 27.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 27.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 15.2 PID_BMP_PATHWAY BMP receptor signaling
0.3 14.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 14.1 PID_ALK1_PATHWAY ALK1 signaling events
0.8 11.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 9.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 8.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.5 8.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 8.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.6 7.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.2 7.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 7.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 6.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.3 4.9 PID_SHP2_PATHWAY SHP2 signaling
0.1 4.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 4.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 4.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 24.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.6 23.2 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 18.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 13.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 11.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 11.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.5 10.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 10.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 9.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 7.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 6.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 6.7 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 6.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.8 6.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.5 5.8 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.4 5.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 5.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 4.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 4.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport