Motif ID: Nfic_Nfib

Z-value: 1.820

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.324.1e-02Click!
Nfibmm10_v2_chr4_-_82505707_82505739-0.192.4e-01Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 28.457 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr6_+_17306335 17.282 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr10_+_57784859 17.072 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr18_-_80986578 16.123 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr14_-_118052235 15.817 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr6_+_135362931 14.905 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr16_+_90831113 12.918 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr1_+_43730593 11.794 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_78322965 11.156 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr10_+_57784914 10.411 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr9_+_44134562 10.281 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr3_+_94933041 9.858 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr7_-_116237767 8.659 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr7_+_45017953 7.513 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chrX_-_48034842 7.277 ENSMUST00000039026.7
 Apln
apelin
chr3_-_116129615 6.761 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr7_+_130936172 6.707 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr11_-_77894096 6.636 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_-_72874877 6.610 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr11_-_94601862 6.600 ENSMUST00000103164.3
 Acsf2
acyl-CoA synthetase family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 39.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.5 27.5 GO:0060134 prepulse inhibition(GO:0060134)
4.6 23.0 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.0 16.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)
2.6 15.8 GO:0006570 tyrosine metabolic process(GO:0006570)
2.5 14.9 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.7 14.4 GO:0032060 bleb assembly(GO:0032060)
1.5 11.8 GO:0070314 G1 to G0 transition(GO:0070314)
2.2 11.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
3.6 10.8 GO:0071918 urea transmembrane transport(GO:0071918)
2.1 10.3 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.2 9.4 GO:0048747 muscle fiber development(GO:0048747)
0.3 8.8 GO:0050873 brown fat cell differentiation(GO:0050873)
1.4 8.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.8 8.7 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.0 8.4 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.2 7.4 GO:0060325 face morphogenesis(GO:0060325)
2.4 7.3 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.6 6.8 GO:0061032 visceral serous pericardium development(GO:0061032)
1.1 6.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 23.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 21.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 20.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 17.6 GO:0030424 axon(GO:0030424)
0.6 15.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
2.1 14.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 13.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.7 11.7 GO:0031045 dense core granule(GO:0031045)
3.4 10.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.8 8.7 GO:0005915 zonula adherens(GO:0005915)
0.1 8.5 GO:0005844 polysome(GO:0005844)
0.0 7.8 GO:0031012 extracellular matrix(GO:0031012)
0.3 7.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 7.4 GO:0005581 collagen trimer(GO:0005581)
0.0 7.1 GO:0001650 fibrillar center(GO:0001650)
0.1 7.0 GO:0042383 sarcolemma(GO:0042383)
0.5 6.9 GO:0097449 astrocyte projection(GO:0097449)
0.3 6.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 6.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.7 6.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 39.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 28.3 GO:0005504 fatty acid binding(GO:0005504)
4.6 23.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.3 16.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
1.4 15.2 GO:0008430 selenium binding(GO:0008430)
0.6 14.9 GO:0051787 misfolded protein binding(GO:0051787)
0.1 12.9 GO:0008201 heparin binding(GO:0008201)
1.9 11.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
2.8 11.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.5 11.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 10.7 GO:0005178 integrin binding(GO:0005178)
2.6 10.3 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.7 8.7 GO:0070097 delta-catenin binding(GO:0070097)
0.0 8.1 GO:0005198 structural molecule activity(GO:0005198)
0.9 7.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 7.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.7 6.8 GO:0008131 primary amine oxidase activity(GO:0008131)
1.7 6.6 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 6.5 GO:0050840 extracellular matrix binding(GO:0050840)
2.0 5.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 23.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 14.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 12.6 NABA_COLLAGENS Genes encoding collagen proteins
0.3 11.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 9.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 9.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 7.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.4 6.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 6.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.5 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 2.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.0 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 1.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.2 1.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 39.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 21.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 14.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 11.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 10.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 8.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 7.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.5 7.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 6.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 5.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 5.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 5.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 5.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 5.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.6 4.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 4.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 4.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 3.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 3.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors