Motif ID: Nfil3_Tef

Z-value: 1.729

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tefmm10_v2_chr15_+_81811414_818114910.803.0e-10Click!
Nfil3mm10_v2_chr13_-_52981027_529810830.371.8e-02Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_40346290 14.846 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr5_+_117841839 13.897 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_-_91459254 12.930 ENSMUST00000069620.8
 Per2
period circadian clock 2
chrX_-_51681703 11.146 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 10.712 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_+_76579670 10.292 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr6_-_113934679 9.900 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr7_+_96211656 9.356 ENSMUST00000107165.1
 Tenm4
teneurin transmembrane protein 4
chr2_-_25469742 9.142 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_66440753 8.783 ENSMUST00000112371.2
ENSMUST00000138910.1
 Scn1a

sodium channel, voltage-gated, type I, alpha

chr1_-_58586191 8.599 ENSMUST00000038372.7
ENSMUST00000097724.3
ENSMUST00000161000.1
ENSMUST00000161600.1
 Fam126b



family with sequence similarity 126, member B



chr2_-_25470031 8.286 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr14_-_18239053 8.260 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr16_-_22439570 6.964 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr17_+_26715644 6.707 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr11_-_101785252 6.443 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr9_+_121366958 6.317 ENSMUST00000045903.6
 Trak1
trafficking protein, kinesin binding 1
chr3_+_51559973 6.088 ENSMUST00000180404.1
 5031434O11Rik
RIKEN cDNA 5031434O11 gene
chr2_+_131909951 5.730 ENSMUST00000124100.1
ENSMUST00000136783.1
 PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chr10_+_127421208 5.634 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 21.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
3.5 17.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
4.6 13.9 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
1.9 13.4 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.3 13.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
4.3 12.9 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
1.7 9.9 GO:0048840 otolith development(GO:0048840)
1.6 9.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.3 9.4 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.4 8.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
1.1 7.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.3 6.7 GO:0051012 microtubule sliding(GO:0051012)
1.3 6.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.9 6.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.6 5.6 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.4 5.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.8 5.5 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
1.0 5.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
1.0 4.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 4.7 GO:0071625 positive regulation of synaptic transmission, glutamatergic(GO:0051968) vocalization behavior(GO:0071625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.7 GO:0016021 integral component of membrane(GO:0016021)
1.1 15.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 14.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 14.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.3 13.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 12.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.4 9.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 9.7 GO:0005730 nucleolus(GO:0005730)
1.4 9.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 6.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 6.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 6.2 GO:0005930 axoneme(GO:0005930)
0.5 5.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 5.5 GO:0016234 inclusion body(GO:0016234)
1.3 5.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 5.2 GO:0009925 basal plasma membrane(GO:0009925)
1.6 4.8 GO:0043512 inhibin A complex(GO:0043512)
0.5 4.7 GO:0005883 neurofilament(GO:0005883)
0.3 4.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 4.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 21.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
4.4 17.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.6 15.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
4.9 14.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 14.6 GO:0005509 calcium ion binding(GO:0005509)
0.8 12.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 10.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.6 9.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 9.6 GO:0051787 misfolded protein binding(GO:0051787)
1.4 8.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.3 7.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 7.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 6.3 GO:0050811 GABA receptor binding(GO:0050811)
0.2 5.6 GO:0004385 guanylate kinase activity(GO:0004385)
1.4 5.5 GO:1903135 cupric ion binding(GO:1903135)
1.3 5.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.7 5.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.8 4.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 4.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 4.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 9.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 7.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 6.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 6.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 6.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 4.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 4.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 4.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 1.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 14.6 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 12.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 12.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 10.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.8 9.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 9.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 8.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 8.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.2 4.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 4.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.8 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 2.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis