Motif ID: Nfix
Z-value: 1.208
Transcription factors associated with Nfix:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfix | ENSMUSG00000001911.10 | Nfix |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfix | mm10_v2_chr8_-_84773381_84773427 | 0.86 | 4.4e-13 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 117 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 25.4 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 1.8 | 20.1 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 1.0 | 15.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 13.1 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.3 | 12.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 2.9 | 8.6 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.3 | 8.3 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.3 | 8.0 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 1.1 | 7.8 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 1.3 | 6.7 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.1 | 6.5 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 1.0 | 6.1 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.3 | 5.7 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.3 | 5.5 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.9 | 5.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.8 | 4.8 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.4 | 4.8 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 1.4 | 4.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 1.3 | 3.8 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.2 | 3.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.5 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 23.8 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 16.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 12.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.9 | 7.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 2.2 | 6.7 | GO:0043512 | inhibin A complex(GO:0043512) |
| 1.6 | 6.4 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 6.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 5.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 4.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 4.8 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 1.0 | 4.1 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.7 | 3.3 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 2.8 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 2.8 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.3 | 2.5 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 2.5 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 1.9 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.6 | GO:0043657 | host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657) |
| 0.1 | 1.5 | GO:0043218 | compact myelin(GO:0043218) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 86 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 25.0 | GO:0005504 | fatty acid binding(GO:0005504) |
| 5.0 | 20.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 19.5 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 10.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 9.3 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 7.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 7.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.2 | 6.5 | GO:0004686 | elongation factor-2 kinase activity(GO:0004686) |
| 0.1 | 6.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 1.6 | 6.4 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 1.0 | 6.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 6.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 5.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 4.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 4.0 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 1.3 | 3.8 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.8 | 3.8 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.2 | 3.8 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 3.4 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.6 | 3.3 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 24 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.2 | 7.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.3 | 6.1 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 5.1 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.5 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.4 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.1 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 2.8 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 2.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 2.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.8 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.7 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.5 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 1.4 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 0.9 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.9 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.9 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.8 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 39 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 20.1 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 10.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 8.4 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 1.7 | 6.7 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.3 | 5.1 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.2 | 4.8 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 4.8 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 3.8 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.3 | 3.3 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 3.2 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.6 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.5 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 2.1 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 2.0 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 1.9 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.8 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.1 | 1.8 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.7 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.5 | REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
