Motif ID: Nfkb2
Z-value: 0.511
Transcription factors associated with Nfkb2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfkb2 | ENSMUSG00000025225.8 | Nfkb2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfkb2 | mm10_v2_chr19_+_46305682_46305741 | -0.45 | 3.0e-03 | Click! |
Top targets:
Showing 1 to 20 of 73 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.9 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 3.4 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.2 | 2.6 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.0 | 1.6 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.1 | 1.3 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 1.3 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 0.4 | 1.1 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
| 0.3 | 1.1 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.2 | 0.9 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.2 | 0.8 | GO:0070942 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) |
| 0.1 | 0.8 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.0 | 0.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.7 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.2 | 0.6 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.1 | 0.6 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.1 | 0.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.6 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 0.5 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.1 | 0.3 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.1 | 0.3 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
Gene overrepresentation in cellular_component category:
Showing 1 to 13 of 13 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 1.2 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.2 | 1.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 1.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 0.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.7 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.6 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.3 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
Showing 1 to 17 of 17 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 1.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.1 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 0.9 | GO:0070976 | calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976) |
| 0.1 | 0.9 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 0.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 0.6 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.0 | 0.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 0.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.3 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.0 | 0.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.3 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
Gene overrepresentation in C2:CP category:
Showing 1 to 8 of 8 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.6 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.6 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.5 | PID_IL23_PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.4 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 1.3 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.9 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.8 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.6 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.6 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.3 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
