Motif ID: Nhlh1

Z-value: 0.983


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_172057598-0.019.7e-01Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_158375638 2.725 ENSMUST00000109488.1
Snhg11
small nucleolar RNA host gene 11
chr13_-_111808938 2.588 ENSMUST00000109267.2
Map3k1
mitogen-activated protein kinase kinase kinase 1
chr16_+_91269759 2.449 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr6_+_104492790 2.306 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
Cntn6


contactin 6


chr13_+_24638636 2.199 ENSMUST00000110384.2
ENSMUST00000058009.9
ENSMUST00000038477.6
Fam65b


family with sequence similarity 65, member B


chrX_+_35888808 2.073 ENSMUST00000033419.6
Dock11
dedicator of cytokinesis 11
chr9_-_57836706 2.014 ENSMUST00000164010.1
ENSMUST00000171444.1
ENSMUST00000098686.3
Arid3b


AT rich interactive domain 3B (BRIGHT-like)


chr11_-_28583995 1.922 ENSMUST00000146385.2
Ccdc85a
coiled-coil domain containing 85A
chr2_-_60963192 1.905 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr14_+_56887795 1.826 ENSMUST00000022511.8
Zmym2
zinc finger, MYM-type 2
chr5_-_72587544 1.794 ENSMUST00000031124.4
Gm5868
predicted gene 5868
chrX_-_162643575 1.712 ENSMUST00000101102.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr2_+_102658640 1.597 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_+_25152456 1.597 ENSMUST00000098678.1
D930028M14Rik
RIKEN cDNA D930028M14 gene
chrX_-_162643629 1.556 ENSMUST00000112334.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr19_+_47014672 1.531 ENSMUST00000037636.3
Ina
internexin neuronal intermediate filament protein, alpha
chr13_-_117025505 1.517 ENSMUST00000022239.6
Parp8
poly (ADP-ribose) polymerase family, member 8
chr9_+_103112072 1.510 ENSMUST00000035155.6
Rab6b
RAB6B, member RAS oncogene family
chr5_-_66618772 1.454 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr6_+_97807014 1.446 ENSMUST00000043637.7
Mitf
microphthalmia-associated transcription factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 412 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 2.9 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.2 2.6 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 2.6 GO:0050821 protein stabilization(GO:0050821)
0.3 2.5 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.2 2.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 2.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 2.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 2.3 GO:0043488 regulation of mRNA stability(GO:0043488)
0.6 2.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.5 2.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 1.8 GO:0090383 phagosome acidification(GO:0090383)
0.2 1.6 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 1.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 1.5 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 1.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0030673 axolemma(GO:0030673)
0.0 4.0 GO:0016605 PML body(GO:0016605)
0.1 3.0 GO:0031941 filamentous actin(GO:0031941)
0.2 2.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.1 GO:0014704 intercalated disc(GO:0014704)
0.3 2.0 GO:0070695 FHF complex(GO:0070695)
0.0 2.0 GO:0000776 kinetochore(GO:0000776)
0.1 1.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 1.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.5 GO:0005883 neurofilament(GO:0005883)
0.5 1.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.1 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0003779 actin binding(GO:0003779)
0.0 5.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.0 GO:0005112 Notch binding(GO:0005112)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 2.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.6 2.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.4 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 2.3 GO:0005109 frizzled binding(GO:0005109)
0.1 2.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 2.1 GO:0031489 myosin V binding(GO:0031489)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.7 GO:0043274 phospholipase binding(GO:0043274)
0.3 1.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.3 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.3 4.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.0 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 0.7 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 3.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 1.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation