Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.588

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 9.710 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 8.140 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr6_-_23248264 5.243 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_140607334 4.505 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_46760526 2.219 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr13_-_102906046 2.201 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr6_-_124779686 2.183 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr5_+_9100681 2.064 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr13_-_102905740 2.026 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_143460989 1.997 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_87108656 1.820 ENSMUST00000051395.8
 Prr11
proline rich 11
chr12_-_40037387 1.678 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr14_-_8666236 1.621 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr19_+_5490475 1.217 ENSMUST00000116560.2
 Cfl1
cofilin 1, non-muscle
chr16_+_52031549 1.207 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr3_+_94372794 1.196 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr4_-_141599835 1.168 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chrX_+_106015699 1.132 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb
chr10_-_88146867 1.064 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr18_+_4993795 1.033 ENSMUST00000153016.1
 Svil
supervillin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0043010 camera-type eye development(GO:0043010)
0.4 8.1 GO:0007530 sex determination(GO:0007530)
0.9 5.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.9 4.5 GO:0007386 compartment pattern specification(GO:0007386)
0.2 2.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 1.2 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.4 1.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 1.2 GO:0019532 oxalate transport(GO:0019532)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 1.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 1.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.1 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.2 0.9 GO:0090365 regulation of mRNA modification(GO:0090365)
0.2 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 0.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.1 0.8 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.2 0.7 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.6 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.2 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.1 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.2 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 8.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.5 4.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 3.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 3.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 1.2 GO:0031005 filamin binding(GO:0031005)
0.1 1.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 0.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 0.8 GO:0034618 arginine binding(GO:0034618)
0.1 0.8 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.2 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex