Motif ID: Nkx2-1

Z-value: 0.671


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.525.7e-04Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_89688196 5.659 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr12_+_103314944 5.547 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr8_-_46294592 5.202 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_88978958 3.867 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr19_+_44493472 3.852 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr11_+_117849223 3.540 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr14_-_47411666 3.528 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr16_+_48994185 2.830 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 2.735 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chrX_+_100730178 2.646 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_57114970 2.644 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr10_+_88091070 2.416 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr14_+_75455957 2.313 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr4_-_141874879 2.180 ENSMUST00000036854.3
 Efhd2
EF hand domain containing 2
chr1_+_97024681 1.995 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr12_+_91400990 1.994 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr4_-_9643638 1.946 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr2_+_121506715 1.785 ENSMUST00000028676.5
 Wdr76
WD repeat domain 76
chr2_+_121506748 1.781 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chr11_-_78550777 1.632 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.3 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.6 5.7 GO:0060179 male mating behavior(GO:0060179)
0.3 5.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 3.9 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.2 3.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.8 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.7 2.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.3 2.6 GO:0090527 actin filament reorganization(GO:0090527)
0.8 2.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.5 2.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 2.0 GO:1904587 response to glycoprotein(GO:1904587)
0.6 1.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 1.6 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.7 1.4 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.0 1.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 1.3 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.1 1.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.3 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.0 4.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.9 GO:0005901 caveola(GO:0005901)
0.2 3.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.6 GO:0005884 actin filament(GO:0005884)
0.3 1.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.1 GO:0002177 manchette(GO:0002177)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.0 4.6 GO:0045296 cadherin binding(GO:0045296)
0.0 3.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 3.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 2.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 2.7 GO:0005272 sodium channel activity(GO:0005272)
0.3 2.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 2.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 2.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 2.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 1.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 5.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.7 2.0 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)