Motif ID: Nkx2-2

Z-value: 1.529


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.095.7e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3018753 9.147 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 9.003 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3034599 8.324 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 7.766 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 7.559 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 7.520 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 7.302 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr3_+_118433797 5.362 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr3_+_5218516 4.754 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr1_-_166002613 3.858 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr19_-_5796924 3.810 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_-_49757257 3.519 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_+_62664279 3.453 ENSMUST00000028257.2
 Gca
grancalcin
chr15_-_10470490 3.021 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr2_-_140170528 2.835 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr1_-_135688094 2.701 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr5_-_123141067 2.687 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chrX_+_9885622 2.637 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr13_-_41487306 2.630 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr15_-_8710734 2.618 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 4.7 GO:0070986 left/right axis specification(GO:0070986)
1.5 4.4 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 3.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.8 3.8 GO:0035063 nuclear speck organization(GO:0035063)
0.3 3.8 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 3.8 GO:0006275 regulation of DNA replication(GO:0006275)
0.2 3.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.5 2.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 2.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.7 2.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 2.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 2.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 2.5 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.1 2.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 2.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.3 1.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.6 1.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 1.8 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0072562 blood microparticle(GO:0072562)
0.2 5.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 4.7 GO:0005882 intermediate filament(GO:0005882)
0.0 3.8 GO:0016607 nuclear speck(GO:0016607)
0.0 3.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 3.1 GO:0000922 spindle pole(GO:0000922)
0.2 2.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 2.7 GO:0043194 axon initial segment(GO:0043194)
0.1 2.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.6 2.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 1.8 GO:0001940 male pronucleus(GO:0001940)
0.3 1.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.1 GO:0016460 myosin II complex(GO:0016460)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0008270 zinc ion binding(GO:0008270)
0.6 5.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 4.6 GO:0008327 methyl-CpG binding(GO:0008327)
1.5 4.4 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 3.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.6 3.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.6 3.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 2.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.3 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 2.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 2.2 GO:0017022 myosin binding(GO:0017022)
0.7 2.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.8 GO:0001848 complement binding(GO:0001848)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 4.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 1.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.2 0.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo