Motif ID: Nkx2-3

Z-value: 0.900


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.533.6e-04Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 15.347 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 12.634 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr6_-_23248264 6.607 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_73271925 6.205 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr6_-_6882068 5.911 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr19_-_59170978 5.425 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr12_+_38780284 5.084 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 4.819 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr13_+_83504032 3.499 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr7_+_144838590 3.442 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr12_-_56535047 3.294 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr19_+_43612299 3.235 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chr2_+_22622183 3.111 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr1_+_6734827 2.997 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr12_+_38781093 2.965 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr5_+_139543889 2.895 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_134236483 2.862 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr1_+_6730051 2.859 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_+_187997821 2.837 ENSMUST00000027906.6
 Esrrg
estrogen-related receptor gamma
chr2_-_166155272 2.775 ENSMUST00000088086.3
 Sulf2
sulfatase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 40.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 6.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.0 5.9 GO:0060166 olfactory pit development(GO:0060166)
0.5 5.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 5.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
1.9 5.6 GO:0021759 globus pallidus development(GO:0021759)
1.4 5.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 5.4 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 4.2 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
1.2 3.5 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.5 3.4 GO:0030916 otic vesicle formation(GO:0030916)
0.5 3.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 3.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.6 3.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 3.0 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 2.9 GO:0021516 dorsal spinal cord development(GO:0021516)
0.3 2.8 GO:0060539 diaphragm development(GO:0060539)
0.1 2.8 GO:0032611 interleukin-1 beta production(GO:0032611)
0.5 2.5 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 2.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 GO:0043034 costamere(GO:0043034)
0.0 4.4 GO:0016607 nuclear speck(GO:0016607)
0.7 4.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 2.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 2.4 GO:0060077 inhibitory synapse(GO:0060077)
0.3 2.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 2.1 GO:0032590 dendrite membrane(GO:0032590)
0.4 2.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 2.0 GO:0005818 aster(GO:0005818)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.9 GO:0001940 male pronucleus(GO:0001940)
0.2 1.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 1.2 GO:0098536 deuterosome(GO:0098536)
0.1 1.2 GO:0005916 fascia adherens(GO:0005916)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 0.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 0.9 GO:0005677 chromatin silencing complex(GO:0005677)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 12.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.9 11.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 9.4 GO:0071837 HMG box domain binding(GO:0071837)
0.3 5.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.1 5.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.1 4.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 4.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 3.8 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 3.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.4 3.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 2.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 2.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 2.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 2.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 2.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.4 1.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 41.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 3.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 3.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 3.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.3 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.9 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors