Motif ID: Nkx2-4

Z-value: 0.528


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.028.9e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_4611971 3.237 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr15_+_99055164 2.446 ENSMUST00000047104.7
ENSMUST00000024249.3
Prph

peripherin

chr1_+_178798438 2.094 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr7_-_115824699 1.964 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr13_+_65512678 1.941 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr12_-_91746020 1.815 ENSMUST00000166967.1
Ston2
stonin 2
chr13_+_108316395 1.814 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr2_+_25180737 1.777 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr14_-_47418407 1.717 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr9_+_108560422 1.717 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr13_-_66852017 1.627 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr10_+_88091070 1.551 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr6_+_30568367 1.484 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr11_-_102579461 1.448 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr15_-_26895049 1.422 ENSMUST00000059204.9
Fbxl7
F-box and leucine-rich repeat protein 7
chr5_+_32136458 1.415 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr1_+_97024681 1.271 ENSMUST00000054664.7
Gm6430
predicted gene 6430
chr10_+_20347788 1.019 ENSMUST00000169712.1
Mtfr2
mitochondrial fission regulator 2
chr7_-_34812677 0.945 ENSMUST00000078686.6
Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr10_+_128232065 0.929 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 2.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.7 2.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 2.1 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.2 2.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 1.8 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.3 1.7 GO:0006177 GMP biosynthetic process(GO:0006177)
0.5 1.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 1.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 0.9 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 0.9 GO:0016486 peptide hormone processing(GO:0016486)
0.2 0.8 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.0 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.7 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 0.6 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.8 2.4 GO:0044299 C-fiber(GO:0044299)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.0 2.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.1 0.6 GO:0032009 early phagosome(GO:0032009)
0.1 0.5 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.4 1.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 0.9 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.5 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits