Motif ID: Nkx3-1

Z-value: 0.709


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_132757162 5.263 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr10_-_13324160 4.802 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr3_-_57575760 4.684 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 4.637 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chrX_+_100625737 3.918 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr9_+_78191966 3.871 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr18_+_60963517 2.893 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_+_72438534 2.521 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr6_+_128362919 2.418 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr10_-_13324250 2.274 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr5_+_136919137 2.265 ENSMUST00000181045.1
 4933404O12Rik
RIKEN cDNA 4933404O12 gene
chr1_-_163289214 2.264 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr9_+_72438519 2.228 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr3_-_104818539 2.227 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr8_+_114133557 2.167 ENSMUST00000073521.5
ENSMUST00000066514.6
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr8_+_114133635 2.127 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr17_+_56304313 2.101 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr9_-_124493793 1.860 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr5_-_8422582 1.782 ENSMUST00000168500.1
ENSMUST00000002368.9
 Dbf4

DBF4 homolog (S. cerevisiae)

chr17_-_25727364 1.733 ENSMUST00000170070.1
ENSMUST00000048054.7
 Chtf18

CTF18, chromosome transmission fidelity factor 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 9.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 5.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 4.7 GO:0070986 left/right axis specification(GO:0070986)
1.4 4.3 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.4 3.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 3.4 GO:0051639 actin filament network formation(GO:0051639)
0.2 2.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 2.9 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.2 2.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 2.3 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.2 GO:0006379 mRNA cleavage(GO:0006379)
0.1 2.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.4 1.8 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 1.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 1.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.5 1.5 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 1.4 GO:0015914 phospholipid transport(GO:0015914)
0.3 1.3 GO:0002666 positive regulation of T cell tolerance induction(GO:0002666)
0.1 1.3 GO:0019240 citrulline biosynthetic process(GO:0019240)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.7 GO:0005882 intermediate filament(GO:0005882)
0.0 4.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.4 GO:0032420 stereocilium(GO:0032420)
0.1 3.1 GO:0005871 kinesin complex(GO:0005871)
1.0 2.9 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 2.1 GO:0000791 euchromatin(GO:0000791)
0.2 1.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.0 GO:0070938 contractile ring(GO:0070938)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.8 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.6 GO:0097342 ripoptosome(GO:0097342)
0.1 0.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 5.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.4 4.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 3.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 2.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 2.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.3 GO:0071837 HMG box domain binding(GO:0071837)
0.5 2.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 2.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 1.5 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 1.3 GO:0034618 arginine binding(GO:0034618)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.1 GO:0042169 SH2 domain binding(GO:0042169)
0.2 1.0 GO:0042731 PH domain binding(GO:0042731)
0.1 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.0 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 1.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.8 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 1.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.5 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation