Motif ID: Nkx3-2

Z-value: 0.607


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 3.292 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_-_104409992 2.773 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr15_-_66969616 2.465 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr5_-_139130159 2.229 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr9_-_58313189 2.218 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr9_+_57940104 2.192 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr11_+_3332426 2.113 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr15_-_88978958 2.019 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr1_+_172341197 1.917 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr16_+_41532851 1.824 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr14_+_80000292 1.755 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_+_38965515 1.735 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr15_-_102625061 1.626 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
 ATF7


Cyclic AMP-dependent transcription factor ATF-7


chr4_+_102421518 1.543 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_156992021 1.506 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
 Ndrg3


N-myc downstream regulated gene 3


chr3_-_82074639 1.485 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr6_-_125494754 1.459 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr15_-_102624922 1.449 ENSMUST00000183765.1
 ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr9_-_21037775 1.417 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr15_-_100584075 1.408 ENSMUST00000184908.1
 POU6F1
POU domain, class 6, transcription factor 1 (Pou6f1), mRNA

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 3.0 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 2.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.6 2.3 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.2 2.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.3 2.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 2.0 GO:0071397 cellular response to cholesterol(GO:0071397)
0.5 1.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 1.8 GO:0050777 negative regulation of immune response(GO:0050777)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 1.5 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 1.5 GO:0030913 paranodal junction assembly(GO:0030913)
0.1 1.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 1.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 1.1 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 2.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.3 GO:0097440 apical dendrite(GO:0097440)
0.1 1.9 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.9 GO:0005604 basement membrane(GO:0005604)
0.0 1.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.1 1.7 GO:0005605 basal lamina(GO:0005605)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 3.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.5 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.2 2.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.2 2.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 2.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.7 2.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.6 1.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.1 1.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 1.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 1.4 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.4 GO:0000149 SNARE binding(GO:0000149)
0.1 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 0.8 GO:0010698 acetyltransferase activator activity(GO:0010698)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.6 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.0 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 1.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.8 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.1 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 0.7 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 0.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation