Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.759

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_1016652260.296.8e-02Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98053415 12.009 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr5_-_62766153 10.832 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_18818895 8.785 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr1_-_155417394 6.825 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr3_-_49757257 6.568 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chrX_-_143933089 5.073 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_+_23415400 4.962 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr6_-_101377897 4.821 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr13_+_94083490 4.629 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr16_-_97170707 4.103 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr8_-_34965631 3.948 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_113812547 3.625 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr4_+_108719649 3.548 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr5_-_84417359 3.531 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr1_-_24612700 3.374 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chrM_+_9870 3.345 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr16_+_42907563 3.286 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr9_-_55919605 3.273 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr4_-_155056784 3.271 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr9_-_96719404 3.174 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 234 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.6 9.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 7.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 6.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 6.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 5.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 4.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 4.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.6 4.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.4 4.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
1.4 4.1 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.0 4.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 4.0 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
1.3 3.9 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.5 3.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 3.4 GO:0007416 synapse assembly(GO:0007416)
0.6 3.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 3.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 3.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 3.1 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 8.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.4 GO:0072562 blood microparticle(GO:0072562)
0.4 6.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 6.0 GO:0030427 site of polarized growth(GO:0030427)
0.1 5.8 GO:0031672 A band(GO:0031672)
0.0 5.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.5 GO:0001726 ruffle(GO:0001726)
0.5 4.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 4.2 GO:0071565 nBAF complex(GO:0071565)
0.2 4.2 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 3.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.8 GO:0042641 actomyosin(GO:0042641)
0.9 3.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 3.0 GO:0030139 endocytic vesicle(GO:0030139)
0.1 2.8 GO:0097440 apical dendrite(GO:0097440)
0.0 2.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.8 2.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 2.4 GO:0051286 cell tip(GO:0051286)
0.0 2.3 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 12.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 12.1 GO:0005096 GTPase activator activity(GO:0005096)
3.2 9.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 9.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 8.1 GO:0008017 microtubule binding(GO:0008017)
0.2 4.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 4.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.6 4.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 4.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 4.1 GO:0017124 SH3 domain binding(GO:0017124)
0.2 3.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6 3.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 3.6 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 3.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.6 2.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.3 2.7 GO:0019865 immunoglobulin binding(GO:0019865)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.4 PID_ARF6_PATHWAY Arf6 signaling events
0.2 8.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 7.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 4.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 4.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 3.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 9.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 7.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 5.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 4.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 4.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.2 3.3 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2 3.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.0 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 2.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 1.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 1.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.4 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)