Motif ID: Nkx6-2

Z-value: 0.498


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.134.1e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22161450 2.107 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_-_144209471 1.841 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr17_-_48432723 1.777 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr6_-_144209558 1.764 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr10_+_37139558 1.424 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr4_-_97584605 1.416 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_144209448 1.356 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr4_-_97584612 1.341 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_-_61902669 1.236 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr15_-_13173607 1.013 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr19_+_58728887 0.954 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr1_-_126830632 0.878 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr1_-_126830786 0.864 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr4_-_83285141 0.822 ENSMUST00000150522.1
 Ttc39b
tetratricopeptide repeat domain 39B
chr10_+_26822560 0.773 ENSMUST00000135866.1
 Arhgap18
Rho GTPase activating protein 18
chr5_+_92809372 0.719 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr5_+_92683625 0.717 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr1_+_194619815 0.678 ENSMUST00000027952.5
 Plxna2
plexin A2
chr1_+_66321708 0.660 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr5_+_123142187 0.659 ENSMUST00000174836.1
ENSMUST00000163030.2
 Setd1b

SET domain containing 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 2.5 GO:0051028 mRNA transport(GO:0051028)
0.6 1.8 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 1.4 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 1.2 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.0 1.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 0.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 0.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.6 GO:0097352 autophagosome maturation(GO:0097352)
0.2 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.4 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.1 0.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.3 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 1.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.7 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.5 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.2 GO:0001530 lipopolysaccharide binding(GO:0001530)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase