Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.454

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.362.2e-02Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 2.778 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_+_94083490 2.691 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr5_-_62766153 1.811 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_11406618 1.701 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr17_-_81649607 1.542 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr5_-_70842617 1.485 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr4_+_118961578 1.311 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr13_+_83732438 1.292 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr10_-_110000219 1.197 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr4_+_102589687 1.180 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chrX_-_143933089 1.043 ENSMUST00000087313.3
 Dcx
doublecortin
chr8_-_21906412 1.042 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr3_-_116712644 1.019 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr11_+_109543694 0.997 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr17_+_26715644 0.977 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr5_+_144100387 0.953 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr2_-_160619971 0.947 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr9_-_15301555 0.938 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr6_-_137169710 0.897 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr13_-_105054895 0.848 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 1.5 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.3 1.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.3 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.4 1.1 GO:0015866 ADP transport(GO:0015866)
0.2 1.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 1.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 1.0 GO:0033572 transferrin transport(GO:0033572)
0.1 0.8 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.8 GO:0030903 notochord development(GO:0030903)
0.1 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.6 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.2 0.5 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.4 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.1 0.4 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 0.7 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 1.5 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 1.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.4 1.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters