Motif ID: Nr1h2

Z-value: 1.149


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.533.6e-04Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 13.396 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 8.882 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr10_-_109823585 7.765 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr16_-_37384915 7.162 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr11_+_84179792 6.099 ENSMUST00000137500.2
ENSMUST00000130012.2
 Acaca

acetyl-Coenzyme A carboxylase alpha

chr3_-_148989316 5.349 ENSMUST00000098518.2
 Lphn2
latrophilin 2
chr5_-_124327883 5.015 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr11_+_84179852 4.961 ENSMUST00000136463.2
 Acaca
acetyl-Coenzyme A carboxylase alpha
chr8_-_84773381 4.782 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_113829069 4.724 ENSMUST00000024005.7
 Scg5
secretogranin V
chr16_-_37384940 4.712 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr13_-_12461432 4.329 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
 Lgals8



lectin, galactose binding, soluble 8



chr13_+_44729794 4.280 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr3_+_62419668 4.226 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_+_76840597 3.708 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
 C530008M17Rik


RIKEN cDNA C530008M17 gene


chr11_-_60210410 3.625 ENSMUST00000144942.1
 Srebf1
sterol regulatory element binding transcription factor 1
chr5_-_100159261 3.588 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr2_+_102658640 3.526 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_+_79895017 3.493 ENSMUST00000023054.7
 Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr7_+_114768736 2.998 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 13.4 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.5 12.5 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.2 11.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
2.8 11.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.1 5.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.3 4.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 4.7 GO:0016486 peptide hormone processing(GO:0016486)
0.7 4.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 4.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 4.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 3.7 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.6 3.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.5 3.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.0 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.1 2.9 GO:0009988 cell-cell recognition(GO:0009988)
0.5 2.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 2.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 2.4 GO:0007141 male meiosis I(GO:0007141)
0.1 2.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 2.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 13.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 8.4 GO:0001650 fibrillar center(GO:0001650)
0.0 6.9 GO:0005635 nuclear envelope(GO:0005635)
0.1 5.9 GO:0005776 autophagosome(GO:0005776)
0.0 5.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 4.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.8 GO:0030141 secretory granule(GO:0030141)
0.1 3.5 GO:0030673 axolemma(GO:0030673)
0.0 2.9 GO:0005814 centriole(GO:0005814)
0.5 2.8 GO:0008091 spectrin(GO:0008091)
0.0 2.4 GO:0030426 growth cone(GO:0030426)
0.1 2.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.9 GO:0043196 varicosity(GO:0043196)
0.4 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0000793 condensed chromosome(GO:0000793)
0.2 1.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.4 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 11.9 GO:0019905 syntaxin binding(GO:0019905)
3.7 11.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 4.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 4.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 4.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.0 3.7 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.9 3.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.6 3.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.8 GO:0051213 dioxygenase activity(GO:0051213)
0.2 2.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 2.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 2.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 2.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 4.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 2.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.3 2.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 13.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 8.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 3.6 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 3.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 2.4 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 2.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 2.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 1.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters