Motif ID: Nr1h4

Z-value: 0.656


Transcription factors associated with Nr1h4:

Gene SymbolEntrez IDGene Name
Nr1h4 ENSMUSG00000047638.9 Nr1h4



Activity profile for motif Nr1h4.

activity profile for motif Nr1h4


Sorted Z-values histogram for motif Nr1h4

Sorted Z-values for motif Nr1h4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h4

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 3.906 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr4_+_53440388 2.570 ENSMUST00000102911.3
ENSMUST00000107646.2
 Slc44a1

solute carrier family 44, member 1

chr10_+_13966268 2.392 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_-_44670820 2.349 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr8_+_94179089 2.090 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr9_-_42399709 2.038 ENSMUST00000160940.1
 Tecta
tectorin alpha
chr7_+_19176416 1.900 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr10_-_33995054 1.832 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chr1_+_172341197 1.762 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_+_80287234 1.723 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr7_-_105482197 1.557 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr5_-_147725988 1.410 ENSMUST00000110529.1
ENSMUST00000031652.3
ENSMUST00000031653.5
 Flt1


FMS-like tyrosine kinase 1


chr9_+_54538984 1.405 ENSMUST00000060242.5
ENSMUST00000118413.1
 Sh2d7

SH2 domain containing 7

chr2_-_152951547 1.353 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chrX_+_73064787 1.329 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chr6_+_4902913 1.316 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr4_+_133039482 1.278 ENSMUST00000105914.1
 Ahdc1
AT hook, DNA binding motif, containing 1
chr7_-_99695809 1.189 ENSMUST00000107086.2
 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr4_-_141664063 1.111 ENSMUST00000084203.4
 Plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr2_-_152951688 1.077 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 2.6 GO:0015871 choline transport(GO:0015871)
0.0 2.4 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 2.3 GO:0071625 vocalization behavior(GO:0071625)
0.0 2.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 2.2 GO:0007605 sensory perception of sound(GO:0007605)
0.3 2.1 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
0.6 1.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.3 1.9 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.4 1.8 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 1.7 GO:0030431 sleep(GO:0030431)
0.2 1.4 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1 1.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 1.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 1.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 1.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 1.0 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.0 1.0 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 0.9 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.9 GO:0097512 cardiac myofibril(GO:0097512)
0.4 2.3 GO:0097513 myosin II filament(GO:0097513)
0.1 2.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.4 1.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 1.8 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.0 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.1 0.7 GO:0030123 AP-3 adaptor complex(GO:0030123) HOPS complex(GO:0030897)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.6 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.3 GO:0005745 m-AAA complex(GO:0005745)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.6 2.6 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 2.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 2.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.1 GO:0005507 copper ion binding(GO:0005507)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.6 1.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 1.7 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 1.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0034711 inhibin binding(GO:0034711)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.9 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.8 GO:0022841 potassium ion leak channel activity(GO:0022841)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.3 1.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.8 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA