Motif ID: Nr1i2

Z-value: 0.872


Transcription factors associated with Nr1i2:

Gene SymbolEntrez IDGene Name
Nr1i2 ENSMUSG00000022809.4 Nr1i2



Activity profile for motif Nr1i2.

activity profile for motif Nr1i2


Sorted Z-values histogram for motif Nr1i2

Sorted Z-values for motif Nr1i2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 6.670 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr3_+_98013503 4.816 ENSMUST00000079812.6
 Notch2
notch 2
chr16_+_91269759 4.680 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_+_30065333 4.032 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_-_66427469 3.703 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr11_-_26210553 2.911 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr2_+_118111876 2.753 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr14_-_118052235 2.743 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr4_+_54945038 2.479 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr7_+_112679327 2.436 ENSMUST00000106638.2
 Tead1
TEA domain family member 1
chr17_-_78985428 2.367 ENSMUST00000118991.1
 Prkd3
protein kinase D3
chr9_-_54661666 2.286 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr3_+_68869563 2.232 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr5_-_136565432 2.223 ENSMUST00000176172.1
 Cux1
cut-like homeobox 1
chrX_+_100729917 2.207 ENSMUST00000019503.7
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr4_-_148087961 2.162 ENSMUST00000030865.8
 Agtrap
angiotensin II, type I receptor-associated protein
chr16_+_41532999 2.087 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr3_+_66219909 2.073 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr18_+_57142782 2.072 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr11_-_101785252 2.053 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.6 4.8 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
0.4 4.3 GO:0014883 transition between fast and slow fiber(GO:0014883)
1.3 4.0 GO:0021557 oculomotor nerve development(GO:0021557)
0.1 4.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
1.2 3.7 GO:0060166 olfactory pit development(GO:0060166)
0.5 3.6 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 3.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 3.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 3.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 3.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.9 2.8 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
0.3 2.8 GO:0042118 endothelial cell activation(GO:0042118)
0.5 2.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 2.7 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 2.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.5 2.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 2.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.4 2.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 2.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.5 GO:0030027 lamellipodium(GO:0030027)
0.0 5.8 GO:0043235 receptor complex(GO:0043235)
0.0 4.7 GO:0016363 nuclear matrix(GO:0016363)
1.1 4.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 3.5 GO:0031430 M band(GO:0031430)
0.0 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.9 2.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 2.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.4 GO:0005903 brush border(GO:0005903)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)
0.1 1.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.8 GO:0097542 ciliary tip(GO:0097542)
0.2 1.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.1 1.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 5.5 GO:0030371 translation repressor activity(GO:0030371)
0.1 5.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 4.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.6 4.1 GO:0001849 complement component C1q binding(GO:0001849)
0.1 3.8 GO:0008432 JUN kinase binding(GO:0008432)
0.9 3.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 3.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 3.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 3.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.3 3.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.9 2.8 GO:0070052 collagen V binding(GO:0070052)
0.7 2.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.4 GO:0004697 protein kinase C activity(GO:0004697)
0.4 2.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.3 2.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 4.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 4.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 4.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 1.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 1.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.0 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels