Motif ID: Nr1i3

Z-value: 1.676


Transcription factors associated with Nr1i3:

Gene SymbolEntrez IDGene Name
Nr1i3 ENSMUSG00000005677.8 Nr1i3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1i3mm10_v2_chr1_+_171213969_1712140070.114.8e-01Click!


Activity profile for motif Nr1i3.

activity profile for motif Nr1i3


Sorted Z-values histogram for motif Nr1i3

Sorted Z-values for motif Nr1i3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_166254095 11.203 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr16_+_30065333 9.769 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_-_110061319 9.474 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr1_+_90203980 9.445 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr4_-_137785371 9.054 ENSMUST00000133473.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr7_-_30973464 8.610 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr14_+_46882854 8.581 ENSMUST00000022386.8
ENSMUST00000100672.3
 Samd4

sterile alpha motif domain containing 4

chr7_-_30973367 8.543 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr1_+_87264345 8.001 ENSMUST00000118687.1
ENSMUST00000027472.6
 Efhd1

EF hand domain containing 1

chr1_-_163289214 7.458 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr6_-_72788952 7.456 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr2_+_30078584 7.244 ENSMUST00000045246.7
 Pkn3
protein kinase N3
chr7_-_30973399 7.198 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr4_-_148087961 6.620 ENSMUST00000030865.8
 Agtrap
angiotensin II, type I receptor-associated protein
chr2_+_71529085 6.407 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr9_-_54661870 6.317 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr10_-_120899067 6.289 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr17_+_47505117 5.997 ENSMUST00000183044.1
ENSMUST00000037333.10
 Ccnd3

cyclin D3

chr11_+_78322965 5.797 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr1_+_172499948 5.791 ENSMUST00000111230.1
 Tagln2
transgelin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 611 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.1 24.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.2 20.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.0 18.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 17.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 15.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
3.9 11.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 11.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.6 10.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 10.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.5 10.3 GO:0038092 nodal signaling pathway(GO:0038092)
2.0 10.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
3.3 9.8 GO:0021557 oculomotor nerve development(GO:0021557)
0.4 9.8 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.4 9.7 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 9.7 GO:0031016 pancreas development(GO:0031016)
0.2 9.4 GO:0051310 metaphase plate congression(GO:0051310)
0.4 9.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.0 8.4 GO:0006004 fucose metabolic process(GO:0006004)
0.6 8.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 8.1 GO:0032543 mitochondrial translation(GO:0032543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 30.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 30.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 28.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
4.1 24.4 GO:0061689 tricellular tight junction(GO:0061689)
0.1 23.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 23.5 GO:0031012 extracellular matrix(GO:0031012)
0.3 19.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 18.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 15.6 GO:0000922 spindle pole(GO:0000922)
0.2 15.0 GO:0005657 replication fork(GO:0005657)
0.2 15.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 13.4 GO:0035371 microtubule plus-end(GO:0035371)
0.8 13.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.8 13.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 13.0 GO:0015934 large ribosomal subunit(GO:0015934)
0.6 12.7 GO:0070469 respiratory chain(GO:0070469)
0.2 11.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 11.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 9.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.1 7.7 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 389 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.6 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 28.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.5 20.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.9 19.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 16.9 GO:0030371 translation repressor activity(GO:0030371)
0.6 16.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 13.1 GO:0001054 RNA polymerase I activity(GO:0001054)
3.2 12.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.0 11.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.0 11.5 GO:0008430 selenium binding(GO:0008430)
0.4 11.3 GO:0008432 JUN kinase binding(GO:0008432)
3.4 10.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.4 10.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.1 9.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
3.1 9.4 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.3 9.3 GO:0071837 HMG box domain binding(GO:0071837)
2.3 9.1 GO:0042806 fucose binding(GO:0042806)
0.8 9.0 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.1 9.0 GO:0008013 beta-catenin binding(GO:0008013)
2.2 8.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 25.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 20.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.4 18.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 18.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 15.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 15.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 12.4 PID_PLK1_PATHWAY PLK1 signaling events
0.3 10.0 PID_BARD1_PATHWAY BARD1 signaling events
1.1 9.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 9.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 7.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 7.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.4 6.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 5.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 5.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 4.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 4.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 4.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 56.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.6 29.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 24.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 15.9 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.9 15.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 15.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6 13.8 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 13.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 13.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 12.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 12.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 12.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 12.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.4 11.7 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 10.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 10.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 9.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.9 9.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.5 8.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.9 8.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition