Motif ID: Nr2e3

Z-value: 0.823


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_35215008 7.644 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr6_+_141524379 6.142 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr10_-_109764840 4.400 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr1_+_19103022 4.371 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr6_-_13839916 4.091 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr2_+_65620829 3.859 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr16_+_43510267 3.084 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr5_+_19227046 3.068 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_+_43508118 2.928 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr2_-_45112890 2.857 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr5_-_104021919 2.794 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr4_-_151861698 2.788 ENSMUST00000049790.7
 Camta1
calmodulin binding transcription activator 1
chr3_+_54156039 2.780 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr4_-_151861762 2.766 ENSMUST00000097774.2
 Camta1
calmodulin binding transcription activator 1
chrX_-_143933089 2.727 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_+_32938955 2.703 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr1_-_58424042 2.671 ENSMUST00000034868.7
 Clk1
CDC-like kinase 1
chr4_-_138396438 2.622 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr5_+_19907774 2.449 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr9_+_113812547 2.413 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 8.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.9 7.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.6 6.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 6.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.2 4.9 GO:0006710 androgen catabolic process(GO:0006710)
0.3 4.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 3.4 GO:0005513 detection of calcium ion(GO:0005513)
0.4 3.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 3.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.5 2.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 2.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 2.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 2.7 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.3 2.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 2.2 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.4 2.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 2.1 GO:0030901 midbrain development(GO:0030901)
0.2 2.0 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.5 1.9 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 8.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.8 7.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 5.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.9 GO:0005811 lipid particle(GO:0005811)
0.0 4.7 GO:0005635 nuclear envelope(GO:0005635)
0.2 4.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 3.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 2.8 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.6 2.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.6 2.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 2.1 GO:0005638 lamin filament(GO:0005638)
0.0 2.0 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.0 GO:0030426 growth cone(GO:0030426)
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.2 1.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 8.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 7.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
1.5 6.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 5.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.7 4.9 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 4.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 4.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 3.8 GO:0042805 actinin binding(GO:0042805)
0.1 3.6 GO:0070412 R-SMAD binding(GO:0070412)
0.7 3.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 2.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 2.4 GO:0002162 dystroglycan binding(GO:0002162)
0.2 2.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.0 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.8 6.1 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.3 3.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 2.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 2.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.2 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 2.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.5 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.4 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.0 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle