Motif ID: Nr4a2

Z-value: 0.489


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.444.2e-03Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 6.381 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 3.939 ENSMUST00000068423.3
Cbln2
cerebellin 2 precursor protein
chr9_-_32344237 2.278 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr13_+_94875600 1.744 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr2_-_129699833 1.667 ENSMUST00000028883.5
Pdyn
prodynorphin
chr2_+_121295437 1.578 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr9_-_106656081 1.366 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr2_+_4976113 1.122 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr7_-_100514800 1.112 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr17_+_29360923 0.962 ENSMUST00000024810.6
Fgd2
FYVE, RhoGEF and PH domain containing 2
chr4_-_36136463 0.945 ENSMUST00000098151.2
Lingo2
leucine rich repeat and Ig domain containing 2
chr13_+_93304066 0.854 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr8_+_68880491 0.809 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr8_+_70863127 0.781 ENSMUST00000050921.2
A230052G05Rik
RIKEN cDNA A230052G05 gene
chr6_-_124814288 0.779 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chrX_+_150589907 0.763 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr18_-_56975333 0.719 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chrX_-_142390334 0.706 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr1_+_57845534 0.690 ENSMUST00000169772.1
Spats2l
spermatogenesis associated, serine-rich 2-like
chr2_+_61593077 0.662 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 2.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.7 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 1.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 1.4 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 1.0 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 1.0 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 1.0 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.2 0.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 0.8 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 0.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 0.7 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.7 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.2 0.6 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 0.6 GO:0015866 ADP transport(GO:0015866)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.7 GO:0043679 axon terminus(GO:0043679)
0.0 1.6 GO:0005930 axoneme(GO:0005930)
0.0 1.6 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.8 GO:0042627 chylomicron(GO:0042627)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.3 1.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.6 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 0.6 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.2 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 1.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 1.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines